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Oncology Clinical Trials

Browse 8,863 oncology clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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Iomab-ACT: A Pilot Study of 131-I Apamistamab Followed by CD19-Targeted CAR T-Cell Therapy for Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma

for
B-ALL, DLBCL, B ALL, Dlbcl-Ci, DLBCL Unclassifiable,
Location: Commack NY, Rockville Centre NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT04512716

Early_phase1, Recruiting

Pemetrexed Response in Relation to Tumor Alterations of Gene Status for the Treatment of Patients With Metastatic Urothelial Bladder Cancer and Other Solid Tumors

for
Metastatic Bladder Urothelial Carcinoma,
Location: Chicago IL, Orland Park IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT06630416

Phase2, Recruiting

Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment

for
Roux-en-y Anastomosis Site, Marginal Ulcer,
Location: Boston MA
Sponsor: Christopher C. Thompson, MD, MSc

Sex: All

Age: 18+

Code: NCT06543316

Recruiting

MAGIC AKI: Magnesium for the Prevention of HIOC-Associated AKI

for
Mesothelioma
Location: Boston MA
Sponsor: Brigham and Women's Hospital

Sex: All

Age: 18+

Code: NCT05730816

Phase2, Recruiting

Genetic Testing for the Prevention of Cancer in American Indian Communities (JUNIPER Trial)

for
Hematopoietic and Lymphatic System Neoplasm,
Location: Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06569316

Recruiting

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Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial

for
Breast Cancer
Location: Boston MA, New York NY, Atlanta GA, Nashville TN,
Sponsor: Massachusetts General Hospital

Sex: Female

Age: 18+

Code: NCT03990896

Phase2, Recruiting

Modifying Metabolic Syndrome and Cardiovascular Risk for Prostate Cancer Patients on ADT Using a Risk Factor Modification Program and Continuous Fitbit Monitoring

for
Biochemically Recurrent Prostate Carcinoma,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: Male

Age: 18+

Code: NCT05054296

Phase2, Recruiting

Clear Me: Interception Trial to Detect and Clear Molecular Residual Disease in Patients With High-risk Melanoma

for
Cutaneous Melanoma, Melanoma Stage IV, Mucosal Melanoma
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT06319196

Phase2, Recruiting

GSD VI and GSD IX Natural History

for
Glycogen Storage Disease VI, GLYCOGEN STORAGE DISEASE IXa1,
Location: Durham NC
Sponsor: Duke University

Sex: All

Age: 0 - 70+

Code: NCT04454216

Recruiting

Addressing Tetrachloroethylene Exposure in an Impacted Community

for
Vapors; Inhalation, Cancer, Volatile Organic Compounds
Location: West Lafayette IN
Sponsor: Purdue University

Sex: All

Age: 18 - 70+

Code: NCT05819996

Recruiting

Gadofosveset Trisodium (Ablavar, Gdfos) in Distinguishing Hemangiomas and Metastases: A Prospective Trial

for
Cancer, Metastases, Liver Neoplasms
Location: Toronto
Sponsor: Sunnybrook Health Sciences Centre

Sex: All

Age: 18+

Code: NCT02036008

Recruiting

Nephroureterectomy With and Without Lymph Node Dissection for Upper Tract Urothelial Cell Carcinoma

for
Urothelial Carcinoma
Location: Gainesville FL, Cleveland OH, Springfield IL
Sponsor: Case Comprehensive Cancer Center

Sex: All

Age: 19+

Code: NCT06262516

Recruiting

NeoTAILOR: ABiomarker-directed Approach to Guide Neoadjuvant Therapy for Patients With Stage II/III ER-positive, HER2-negative Breast Cancer

for
Breast Cancer, Cancer of the Breast
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: Female

Age: 18+

Code: NCT05837455

Phase2, Recruiting

Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers

for
Metastatic Non-small Cell Lung Cancer
Location: Boston MA, Commack NY, Uniondale NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT04410796

Phase2, Recruiting

Remote Cognitive Assessment and Wearable Device While Assessing the Impact of Metformin in Patients With History of Cranial Radiation Therapy

for
Malignant Brain Neoplasm
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06377696

Phase2, Recruiting

N10: A Study of Reduced Chemotherapy and Monoclonal Antibody (mAb)-Based Therapy in Children With Neuroblastoma

for
High-risk Neuroblastoma, Neuroblastoma, Childhood Neuroblastoma
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 1 - 19

Code: NCT06528496

Phase2, Recruiting

Rituxan and Abraxane for the Treatment of Patients With Inoperable Stage III and IV Malignant Melanoma

for
Malignant Melanoma of Skin Stage III, Metastatic Melanoma
Location: Encinitas CA
Sponsor: California Cancer Assocaties for Research & Excellence

Sex: All

Age: 18+

Code: NCT02142335

Phase2, Recruiting

Defining Decision Thresholds for Judgments on Health Benefits and Harms: Study Protocol

for
Decision Support Techniques, GRADE Approach
Location: Hamilton
Sponsor: McMaster University

Sex: All

Age: 18 - 70+

Code: NCT05237635

Recruiting

Neoadjuvant Pembrolizumab and Axitinib in Renal Cell Carcinoma With Inferior Vena Cava Tumor Thrombus

for
Renal Cancer, Kidney Cancer, Renal Cell Carcinoma,
Location: Aurora CO, Lone Tree CO, Highlands Ranch CO
Sponsor: University of Colorado, Denver

Sex: All

Age: 18+

Code: NCT05969496

Phase2, Recruiting

Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations

for
Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma,
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18 - 70+

Code: NCT03786796

Phase2, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer