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Oncology Clinical Trials

Browse 8,863 oncology clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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UNC Metastatic Cancer Radiation Therapy Registry

for
Cancer, Metastatic Cancer
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT06306924

Recruiting

Metabolic Impact of Prospective Controlled Mediterranean Type Diets on Prostate Cancer

for
Prostate Cancer
Location: Cleveland OH
Sponsor: Case Comprehensive Cancer Center

Sex: Male

Age: 18+

Code: NCT05590624

Recruiting

Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer

for
Rectal Adenocarcinoma, Stage II Rectal Cancer AJCC v8,
Location: Seattle WA, Portland OR
Sponsor: OHSU Knight Cancer Institute

Sex: All

Age: 18+

Code: NCT05081024

Recruiting

Stereotactic Body Radiotherapy for Patients With Breast Cancer Oligometastasis

for
Breast Cancer
Location: Hamilton
Sponsor: Juravinski Cancer Center

Sex: All

Age: 18+

Code: NCT03295916

Early_phase1, Recruiting

LCI-PED-NOS-EXER-001: Exercise in Pediatric Oncology Patients

for
Pediatric Cancer
Location: Charlotte NC
Sponsor: Wake Forest University Health Sciences

Sex: All

Age: 2 - 25

Code: NCT05058508

Recruiting

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ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors

for
Refractory Cancer, Recurrent Cancer, Solid Tumor, Adult, Cancer
Location: Boston MA, New York NY, Philadelphia PA, Miami FL,
Sponsor: Immatics US, Inc.

Sex: All

Age: 18+

Code: NCT03686124

Phase1, Phase2, Recruiting

Profiling of Radiological Factors in Treatment and Outcomes in Prostate Cancer

for
Prostatic Cancer, Prostatic Neoplams, Prostatic Hyperplasia,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: Male

Age: 18+

Code: NCT03354416

Recruiting

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

for
Melanoma
Location: Providence RI, New Haven CT, Lebanon NH, Quebec,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06246916

Phase3, Recruiting

Cerebrospinal Fluid Biomarkers for Brain Tumors

for
Central Nervous System Neoplasm
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 0+

Code: NCT04692324

Recruiting

Collection of Blood From Patients With Cancer

for
Prostate Cancer, Breast Cancer, Colon Cancer, Lung Cancer,
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT00034216

Recruiting

De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA

for
Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8,
Location: Jacksonville FL, Rochester MN, Scottsdale AZ
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT05541016

Phase2, Recruiting

A Study of Mesothelin-Targeted CAR T-Cell Therapy in People With Esophagogastric Cancer

for
Mesothelin Positive, Mesothelin-Expressing Tumors,
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06623396

Phase1, Recruiting

Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors

for
Anatomic Stage I Breast Cancer American Joint Committee on Cancer (AJCC) v8,
Location: Alhambra CA, Pasadena CA, Burbank CA, Beverly Hills CA,
Sponsor: Jonsson Comprehensive Cancer Center

Sex: Female

Age: 0+

Code: NCT06113016

Phase2, Recruiting

Diet and Cognitive Training in Hematologic Cancer Survivors

for
Cognitive Impairment, Hematologic Malignancy
Location: Birmingham AL
Sponsor: University of Alabama at Birmingham

Sex: All

Age: 21+

Code: NCT05708716

Recruiting

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

for
Non-small Cell Lung Cancer
Location: Stony Brook NY, White Plains NY, Paramus NJ,
Sponsor: BioNTech SE

Sex: All

Age: 18+

Code: NCT06712316

Phase2, Phase3, Recruiting

A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer

for
Advanced Cancer, Metastatic Solid Tumor
Location: New York NY
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 1 - 25

Code: NCT05004116

Phase1, Phase2, Recruiting

Same Day Discharge for Video-Assisted Thoracoscopic Surgery (VATS) Lung Surgery

for
Lung Cancer, Surgery
Location: Montreal
Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

Sex: All

Age: 18+

Code: NCT05583916

Recruiting

Personalized, Adaptive Treatment for Locally Advanced Head and Neck Cancer

for
HPV-Negative Squamous Cell Carcinoma
Location: Chicago IL
Sponsor: University of Chicago

Sex: All

Age: 18+

Code: NCT06005324

Phase1, Recruiting

A First-in-Human Study of SON-DP in Participants With Relapsed/Refractory Intolerant to Standard of Care Therapies for Advanced/Metastatic Solid Tumors

for
Solid Tumor, Breast Cancer, Pancreatic Cancer, Ovarian Cancer,
Location: Huntersville NC, Detroit MI, Houston TX,
Sponsor: Qurgen Inc.

Sex: All

Age: 18+

Code: NCT05989724

Phase1, Recruiting

Young Breast Cancer Survivors Study

for
Breast Cancer
Location: Columbia SC
Sponsor: University of South Carolina

Sex: Female

Age: 18 - 60

Code: NCT05981716

Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer