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Oncology Clinical Trials

Browse 9,238 oncology clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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1

Molecular Epidemiology of Pediatric Germ Cell Tumors

for
Germ Cell Tumor, Germinoma, Teratoma, Embryonal Carcinoma,
Location: Minneapolis MN
Sponsor: Children's Oncology Group

Sex: All

Age: 0+

Code: NCT05564026

Recruiting

A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

for
Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma,
Location: Durham NC, Ann Arbor MI, Houston TX, Dallas TX,
Sponsor: VA Office of Research and Development

Sex: All

Age: 18+

Code: NCT05563766

Phase2, Recruiting

Geriatric Assessment Guided Interventions to Accelerate Functional Recovery After CAR-T Therapy for Patients 60 Years and Older With B-cell Non-Hodgkin Lymphoma or Multiple Myeloma, GOCART Study

for
B-Cell Non-Hodgkin Lymphoma, Multiple Myeloma
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 60+

Code: NCT06052826

Phase2, Recruiting

TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

for
Breast Cancer, HER2-low Breast Cancer, Metastatic Breast Cancer,
Location: Boston MA, New Haven CT, The Bronx NY,
Sponsor: Ana C Garrido-Castro, MD

Sex: All

Age: 18+

Code: NCT06533826

Phase2, Recruiting

Study of COTI-2 as Monotherapy or Combination Therapy for the Treatment of Malignancies

for
Ovarian Cancer, Fallopian Tube Cancer, Endometrial Cancer,
Location: Houston TX
Sponsor: Critical Outcome Technologies Inc.

Sex: All

Age: 18+

Code: NCT02433626

Phase1, Recruiting

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COAST Therapy in Advanced Solid Tumors and Prostate Cancer

for
Prostate Cancer Recurrent, Solid Tumor, Adult
Location: Charleston SC
Sponsor: Medical University of South Carolina

Sex: All

Age: 18+

Code: NCT05036226

Phase1, Phase2, Recruiting

Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity and HPV-negative Oropharyngeal Squamous Cell Carcinoma

for
Locally Recurrent Oral Cavity Squamous Cell Carcinoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06448026

Phase2, Recruiting

Donor T Cell Therapy in Treating Immunocompromised Patients With Adenovirus-Related Disease

for
Hematopoietic and Lymphoid Cell Neoplasm, Immunocompromised
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 0+

Code: NCT03425526

Phase1, Recruiting

Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors

for
Melanoma Stage IV, Solid Tumor
Location: Boston MA, New York NY, Richmond VA, Cincinnati OH,
Sponsor: Georgiamune Inc

Sex: All

Age: 18+

Code: NCT06425926

Phase1, Phase2, Recruiting

Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer

for
Non-small Cell Lung Cancer
Location: Baltimore MD, Pinehurst NC, Athens GA, Glendale CA
Sponsor: Teligene US

Sex: All

Age: 18+

Code: NCT05168566

Phase2, Recruiting

Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the Treatment of Relapsed/Refractory CD19+ Malignancies

for
Acute Lymphoblastic Leukemia, Diffuse Large B Cell Lymphoma
Location: Salt Lake City UT
Sponsor: University of Utah

Sex: All

Age: 18+

Code: NCT06227026

Phase1, Recruiting

Tolerability Study of Trichostatin A In Subjects With Relapsed or Refractory Hematologic Malignancies

for
Relapsed or Refractory Hematologic Malignancies
Location: Hackensack NJ, Washington DC, Lafayette IN, Fairway KS,
Sponsor: Vanda Pharmaceuticals

Sex: All

Age: 18+

Code: NCT03838926

Phase1, Recruiting

Optimizing Surgical Decisions in Young Adults With Breast Cancer

for
Breast Cancer Stage 0, Breast Cancer Stage I,
Location: Boston MA, New Haven CT, New York NY, Durham NC
Sponsor: Weill Medical College of Cornell University

Sex: Female

Age: 18 - 44

Code: NCT06275126

Recruiting

Pharmacogenomics of Asparaginase Induced Hepatotoxicity

for
Acute Lymphoblastic Leukemia
Location: Los Angeles CA
Sponsor: University of Southern California

Sex: All

Age: 18+

Code: NCT03568266

Recruiting

Natural History of Glycosphingolipid Storage Disorders and Glycoprotein Disorders

for
Neurological Regression, Myoclonus, Cherry Red Spot,
Location: Bethesda MD
Sponsor: National Human Genome Research Institute (NHGRI)

Sex: All

Age: 0 - 70+

Code: NCT00029965

Recruiting

International Rare Histiocytic Disorders Registry (IRHDR)

for
Rare Histiocytic Disorders (RHDs),
Location: Boston MA, New York NY, Toronto, Pittsburgh PA,
Sponsor: The Hospital for Sick Children

Sex: All

Age: 0+

Code: NCT02285582

Recruiting

Comparative Effectiveness of Web-based Versus Traditional Adolescent HIV Prevention

for
HIV Infections, Hepatitis, Sexually Transmitted Infections
Location: Jamaica NY, Bronx NY, Brooklyn NY
Sponsor: National Development and Research Institutes, Inc.

Sex: All

Age: 12 - 18

Code: NCT01142882

Recruiting

Pre-operative SABR With and Without Caloric Restriction for Early Stage Breast Cancer

for
Anatomic Stage 0 Breast Cancer AJCC v8,
Location: Philadelphia PA
Sponsor: Thomas Jefferson University

Sex: All

Age: 40+

Code: NCT04959474

Recruiting

Phase I Trial of 5-Fluorouracil (5FU) -Based Therapy in Combination With Hydroxytyrosol (HT) in Patients With Advanced or Metastatic Colorectal Cancer

for
Advanced or Metastatic CRC
Location: Houston TX
Sponsor: The Methodist Hospital Research Institute

Sex: All

Age: 18+

Code: NCT06833866

Phase1, Recruiting

Etiologies, Investigations and Outcomes of Patients Presenting With Hemoptysis

for
Hemoptysis, Haemoptysis, Lung Disease, Pneumonia, Tuberculosis,
Location: Sherbrooke
Sponsor: Université de Sherbrooke

Sex: All

Age: 18+

Code: NCT02913365

Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer