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Oncology Clinical Trials

Browse 9,272 oncology clinical trials enrolling across the United States and Canada. 215 people applied to oncology studies last month. Search by city or state to find one near you.

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Active & ResponsiveNew

Consolidative Metastasis and Primary Directed Therapy (MPDT) for Renal Cell Carcinoma (RCC)

for
Renal Cell Carcinoma
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 18+

Code: NCT06770855

Recruiting
Active & ResponsiveNew

CCR2 PET Imaging Head and Neck Squamous Cell Carcinoma

for
Head and Neck Squamous Cell Carcinoma,
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT07659678

Phase 2, Recruiting
Active & ResponsiveNew

TMZ + RT + 5-ALA + LIDU SDT System for Newly Diagnosed Butterfly Glioma

for
Glioblastom WHO Grade 4, GBM, bGBM, Butterfly GBM,
Location: Buffalo NY
Sponsor: Alpheus Medical, Inc.

Sex: All

Age: 18 - 70+

Code: NCT07862647

Phase 1, Recruiting
Active & ResponsiveNew

DCE-MRI for Neoadjuvant Treatment Assessment in Patients With Borderline Resectable Pancreatic Cancer

for
Borderline Resectable Pancreatic Ductal Adenocarcinoma
Location: Columbus OH
Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT07705919

Phase 1, Phase 2, Recruiting
Active & ResponsiveNew

SMAD4 Tailored Neoadjuvant Therapy for the Treatment of Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma, SMART-PANC Trial

for
Borderline Resectable Pancreatic Ductal Adenocarcinoma,
Location: Chicago IL
Sponsor: Northwestern University

Sex: All

Age: 18+

Code: NCT07748611

Phase 2, Recruiting

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Active & ResponsiveNew

Neuromodulation for Metabolic Dysfunction

for
Spinal Cord Injuries (SCI), Prediabetes / Type 2 Diabetes
Location: Lexington KY
Sponsor: Rahul Sachdeva

Sex: All

Age: 18+

Code: NCT07597161

Recruiting
Active & ResponsiveNew

Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis

for
Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC)
Location: Hamilton
Sponsor: McMaster University

Sex: All

Age: 18+

Code: NCT07341282

Phase 2, Recruiting
Active & Responsive

Maintenance Obinutuzumab in Treating Patients With Central Nervous System Lymphoma Who Have Achieved a Complete or Partial Response

for
Primary Central Nervous System Lymphoma
Location: New York NY, Burlington VT, Hershey PA,
Sponsor: Providence Health & Services

Sex: All

Age: 18+

Code: NCT06175000

Phase 2, Recruiting
Active & Responsive

Phase II Randomized, Placebo- Controlled Study of Intralesional Nivolumab for High-risk Oral Premalignant Lesions

for
Premalignant Lesion
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06561087

Phase 2, Recruiting
Active & Responsive

Nephrotic Syndrome Study Network

for
Minimal Change Disease (MCD), Membranous Nephropathy,
Location: New Hyde Park NY, The Bronx NY, New York NY,
Sponsor: University of Michigan

Sex: All

Age: 0 - 70+

Code: NCT01209000

Recruiting
Active & Responsive

A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors

for
Neuroblastoma, Sarcoma
Location: The Bronx NY, Washington D.C. DC, Columbus OH,
Sponsor: Nationwide Children's Hospital

Sex: All

Age: 1 - 40

Code: NCT05135975

Phase 2, Recruiting
Active & Responsive

Increasing Pre-Surgical Identification of Muscle Invasive Tumor Evaluations Prior to Planned Cystectomy (INSITE)

for
Urothelial Carcinoma,
Location: Philadelphia PA, Omaha NE
Sponsor: Fox Chase Cancer Center

Sex: All

Age: 18+

Code: NCT06396533

Recruiting
Active & Responsive

Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms

for
Barrett Esophagus, Gastroesophageal Reflux,
Location: Baltimore MD, Chapel Hill NC, Cleveland OH, Aurora CO
Sponsor: Case Comprehensive Cancer Center

Sex: All

Age: 50+

Code: NCT06687603

Recruiting
Active & Responsive

CAR-T Cell Therapy for Desensitization in Kidney Transplantation

for
Kidney Transplant, Kidney Failure,
Location: Boston MA, New York NY, Philadelphia PA
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All

Age: 18 - 65

Code: NCT06056102

Phase 1, Recruiting
Active & Responsive

Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders

for
Langerhan's Cell Histiocytosis, Juvenile Xanthogranuloma,
Location: Boston MA, New York NY, Baltimore MD,
Sponsor: Carl Allen

Sex: All

Age: 0+

Code: NCT04079179

Phase 2, Recruiting
Active & Responsive

All-Trans Retinoic Acid (ATRA) Plus PD-1 Inhibition in Recurrent IDH-Mutant Glioma

for
Glioma, IDH Mutation, Astrocytoma, Oligodendroglioma
Location: Philadelphia PA
Sponsor: Stephen Bagley, MD, MSCE

Sex: All

Age: 18+

Code: NCT05345002

Phase 2, Recruiting
Active & Responsive

Intralesional 5-Fluorouracil (5FU), Topical Calcipotriene Treatment for SCC

for
Carcinoma, Squamous Cell
Location: Pittsburgh PA
Sponsor: Melissa Pugliano-Mauro

Sex: All

Age: 18+

Code: NCT03370406

Phase 1, Recruiting
Active & Responsive

Support and Outreach to Increase Screening for Lung Cancer in Patients With a History of Smoking

for
Lung Carcinoma, Tobacco-Related Carcinoma
Location: Philadelphia PA
Sponsor: Ronald Myers

Sex: All

Age: 50 - 70+

Code: NCT05679349

Recruiting
Active & Responsive

A Phase II Evaluation of Afatinib in Patients With Persistent or Recurrent HER2-positive Uterine Serous Carcinoma

for
HER2/Neu+ Uterine Serous Carcinoma
Location: New Haven CT
Sponsor: Yale University

Sex: Female

Age: 18 - 70+

Code: NCT02491099

Phase 2, Recruiting
Active & Responsive

Low Dose Tamoxifen With or Without Omega-3 Fatty Acids for Breast Cancer Risk Reduction

for
Breast Atypical Hyperplasia, Breast Carcinoma,
Location: Columbus OH, Ann Arbor MI, Kansas City KS
Sponsor: National Cancer Institute (NCI)

Sex: Female

Age: 45 - 70+

Code: NCT06195306

Phase 2, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer