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Paid Clinical Trials Irvine

Discover 3,580 paid clinical trials in Irvine, California. Search by condition or phase to find a research study near you that matches your needs across various therapeutic areas.

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A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)

for
Endometrial Cancer
Location: Irvine CA, Orange CA, Solvang CA, Walnut Creek CA,
Sponsor: Merck Sharp & Dohme LLC

Sex: Female

Age: 18+

Code: NCT06952504

Phase3, Recruiting

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

for
Castration-Resistant Prostate Carcinoma,
Location: Irvine CA, Orange CA, Encinitas CA, La Jolla CA,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 18+

Code: NCT06632977

Phase2, Recruiting

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

for
Cutaneous Melanoma, Stage II
Location: Irvine CA, Orange CA, Los Angeles CA, Pasadena CA,
Sponsor: Melanoma and Skin Cancer Trials Limited

Sex: All

Age: 18+

Code: NCT03860883

Recruiting

Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

for
Retroperitoneal Sarcoma, Liposarcoma, Leiomyosarcoma
Location: Irvine CA, Orange CA, Duarte CA, La Jolla CA,
Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All

Age: 18+

Code: NCT04031677

Phase3, Recruiting

Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors

for
Acneiform Eruption Due to Chemical, Xerosis Cutis, Paronychia
Location: Irvine CA, Orange CA, Houston TX, Canton OH, Miami FL,
Sponsor: Hoth Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05639933

Phase2, Recruiting

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Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma

for
Diffuse Large B-Cell Lymphoma, Grade 3b Follicular Lymphoma,
Location: Irvine CA, Costa Mesa CA, Orange CA, Laguna Hills CA,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT05633615

Phase2, Recruiting

Pembrolizumab Plus CA-4948 for the Treatment of Patients With Progressive Metastatic Urothelial Cancer Despite Prior Immunotherapy

for
Metastatic Urothelial Carcinoma,
Location: Irvine CA, Orange CA, Duarte CA, La Jolla CA, Dallas TX,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06439836

Phase1, Recruiting

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

for
Classic Follicular Lymphoma,
Location: Irvine CA, Orange CA, Yorba Linda CA, Long Beach CA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06337318

Phase3, Recruiting

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

for
Acute Myeloid Leukemia,
Location: Irvine CA, Orange CA, Los Angeles CA, Las Vegas NV,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05564390

Phase2, Recruiting

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

for
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Location: Irvine CA, Newport Beach CA, Costa Mesa CA, Orange CA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT04269902

Phase3, Recruiting

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

for
Prostate Adenocarcinoma, Stage III Prostate Cancer AJCC v8,
Location: Irvine CA, Orange CA, Torrance CA, Beverly Hills CA,
Sponsor: NRG Oncology

Sex: Male

Age: 18+

Code: NCT05946213

Phase3, Recruiting

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

for
Metastatic Renal Cell Carcinoma,
Location: Irvine CA, Orange CA, Los Angeles CA, Beverly Hills CA,
Sponsor: NRG Oncology

Sex: All

Age: 18+

Code: NCT05327686

Phase2, Recruiting

Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial

for
Advanced Hepatocellular Carcinoma,
Location: Irvine CA, Orange CA, Portland OR, Pittsburgh PA
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06811116

Phase1, Phase2, Recruiting

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

for
Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
Location: Irvine CA, Newport Beach CA, Costa Mesa CA, Orange CA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 5 - 60

Code: NCT05675410

Phase3, Recruiting

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

for
Metastatic Colorectal Adenocarcinoma,
Location: Irvine CA, Orange CA, Beverly Hills CA, Los Angeles CA,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 18+

Code: NCT05673148

Phase2, Recruiting

Study of Targeted Therapy vs. Chemotherapy in Patients With Thyroid Cancer

for
Refractory Differentiated Thyroid Gland Carcinoma
Location: Irvine CA, Orange CA, Burbank CA, Palo Alto CA, Napa CA,
Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All

Age: 18+

Code: NCT06475989

Phase3, Recruiting

Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors

for
Metastatic Malignant Neoplasm in the Liver,
Location: Irvine CA, Newport Beach CA, Orange CA,
Sponsor: SWOG Cancer Research Network

Sex: All

Age: 18+

Code: NCT05040360

Phase2, Recruiting

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

for
Urothelial Carcinoma
Location: Irvine CA, Newport Beach CA, Orange CA, Anaheim CA,
Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All

Age: 18+

Code: NCT04879329

Phase2, Recruiting

Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer

for
Clear Cell Renal Cell Carcinoma, Renal Cell Carcinoma (RCC),
Location: Irvine CA, Newport Beach CA, Orange CA, Upland CA,
Sponsor: Alliance for Clinical Trials in Oncology

Sex: All

Age: 18+

Code: NCT06661720

Phase3, Recruiting

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

for
Metastatic Castration-resistant Prostate Cancer (mCRPC),
Location: Irvine CA, Orange CA, Riverside CA, Los Angeles CA,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06136650

Phase3, Recruiting