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Oncology Clinical Trials

Browse 8,120 oncology clinical trials enrolling across the United States and Canada. 218 people applied to oncology studies last month. Search by city or state to find one near you.

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Disease Outcomes and Toxicities in Patients With Gastrointestinal and Sarcomatous Malignancies

for
Sarcoma, Gastrointestinal Cancer
Location: Chapel Hill NC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT05743426

Recruiting

Molecular and Clinical Risk-Directed Therapy for Infants and Young Children With Newly Diagnosed Medulloblastoma

for
Medulloblastoma
Location: Orlando FL, Tampa FL, Ann Arbor MI, Memphis TN,
Sponsor: St. Jude Children's Research Hospital

Sex: All

Age: 0 - 4

Code: NCT05535166

Phase 2, Recruiting

A Study of EP0031 (Lunbotinib) in Patients With Advanced RET-altered Malignancies

for
NSCLC
Location: Boston MA, New York NY, Washington D.C. DC, Fairfax VA,
Sponsor: Ellipses Pharma

Sex: All

Age: 18+

Code: NCT05443126

Phase 1, Phase 2, Recruiting

CyberKnife Stereotactic Radiosurgery for Low and Intermediate Risk Prostate Cancer

for
Prostate Cancer
Location: Riverside CA
Sponsor: Riverside Community Hospital, California

Sex: Male

Age: 18+

Code: NCT02070952

Recruiting

Transrectal Ultrasound Robot-Assisted Prostate Biopsy

for
Prostate Cancer
Location: Baltimore MD
Sponsor: Johns Hopkins University

Sex: Male

Age: 45 - 70+

Code: NCT02871726

Recruiting

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Molecular Epidemiology of Pediatric Germ Cell Tumors

for
Germ Cell Tumor, Germinoma, Teratoma, Embryonal Carcinoma,
Location: Minneapolis MN
Sponsor: Children's Oncology Group

Sex: All

Age: 0+

Code: NCT05564026

Recruiting

A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal Cancer

for
Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma,
Location: Durham NC, Ann Arbor MI, Houston TX, Dallas TX,
Sponsor: VA Office of Research and Development

Sex: All

Age: 18+

Code: NCT05563766

Phase 2, Recruiting

Geriatric Assessment Guided Interventions to Accelerate Functional Recovery After CAR-T Therapy for Patients 60 Years and Older With B-cell Non-Hodgkin Lymphoma or Multiple Myeloma, GOCART Study

for
B-Cell Non-Hodgkin Lymphoma, Multiple Myeloma
Location: Winston-Salem NC, Columbus OH, Irvine CA, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 60+

Code: NCT06052826

Phase 2, Recruiting

TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

for
Breast Cancer, HER2-low Breast Cancer, Metastatic Breast Cancer,
Location: Boston MA, New Haven CT, The Bronx NY,
Sponsor: Ana C Garrido-Castro, MD

Sex: All

Age: 18+

Code: NCT06533826

Phase 2, Recruiting

Study of COTI-2 as Monotherapy or Combination Therapy for the Treatment of Malignancies

for
Ovarian Cancer, Fallopian Tube Cancer, Endometrial Cancer,
Location: Houston TX
Sponsor: Critical Outcome Technologies Inc.

Sex: All

Age: 18+

Code: NCT02433626

Phase 1, Recruiting

The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL Trial

for
Rectal Cancer, Colorectal Cancer, Rectal Cancer Stage II,
Location: Boston MA
Sponsor: Dana-Farber Cancer Institute

Sex: All

Age: 18+

Code: NCT06565052

Recruiting

Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity and HPV-negative Oropharyngeal Squamous Cell Carcinoma

for
Locally Recurrent Oral Cavity Squamous Cell Carcinoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06448026

Phase 2, Recruiting

Donor T Cell Therapy in Treating Immunocompromised Patients With Adenovirus-Related Disease

for
Hematopoietic and Lymphoid Cell Neoplasm, Immunocompromised
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 0+

Code: NCT03425526

Phase 1, Recruiting

Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF).

for
NF1, Cutaneous Neurofibroma, Monotherapy
Location: Baltimore MD
Sponsor: Johns Hopkins University

Sex: All

Age: 18+

Code: NCT06159166

Phase 1, Phase 2, Recruiting

Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors

for
Melanoma Stage IV, Solid Tumor
Location: Boston MA, New York NY, Richmond VA, Cincinnati OH,
Sponsor: Georgiamune Inc

Sex: All

Age: 18+

Code: NCT06425926

Phase 1, Phase 2, Recruiting

Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer

for
Non-small Cell Lung Cancer
Location: Baltimore MD, Washington D.C. DC, Fairfax VA,
Sponsor: Teligene US

Sex: All

Age: 18+

Code: NCT05168566

Phase 2, Recruiting

Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CAR-T Cells) for the Treatment of Relapsed/Refractory CD19+ Malignancies

for
Acute Lymphoblastic Leukemia, Diffuse Large B Cell Lymphoma
Location: Salt Lake City UT
Sponsor: University of Utah

Sex: All

Age: 18+

Code: NCT06227026

Phase 1, Recruiting

Tolerability Study of Trichostatin A In Subjects With Relapsed or Refractory Hematologic Malignancies

for
Relapsed or Refractory Hematologic Malignancies
Location: Hackensack NJ, Washington DC, Lafayette IN, Fairway KS,
Sponsor: Vanda Pharmaceuticals

Sex: All

Age: 18+

Code: NCT03838926

Phase 1, Recruiting

Optimizing Surgical Decisions in Young Adults With Breast Cancer

for
Breast Cancer Stage 0, Breast Cancer Stage I,
Location: Boston MA, New Haven CT, New York NY, Durham NC
Sponsor: Weill Medical College of Cornell University

Sex: Female

Age: 18 - 44

Code: NCT06275126

Recruiting

Pharmacogenomics of Asparaginase Induced Hepatotoxicity

for
Acute Lymphoblastic Leukemia
Location: Los Angeles CA
Sponsor: University of Southern California

Sex: All

Age: 18+

Code: NCT03568266

Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer