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Oncology Clinical Trials

Browse 8,120 oncology clinical trials enrolling across the United States and Canada. 218 people applied to oncology studies last month. Search by city or state to find one near you.

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Active & Responsive

A Study of ASP2138 Given Before Surgery, Then Chemotherapy After Surgery, in People With Pancreatic Ductal Cancer

for
Pancreatic Ductal Adenocarcinoma
Location: Boston MA, New York NY, Durham NC
Sponsor: Astellas Pharma Global Development, Inc.

Sex: All

Age: 18+

Code: NCT07024615

Phase 1, Recruiting
Active & Responsive

A Study of Lonitoclax (ZE50-0134) in Relapsed or Refractory B-cell Malignancies

for
CLL / SLL, CLL (Chronic Lymphocytic Leukemia),
Location: Chapel Hill NC, Columbus OH, Cincinnati OH,
Sponsor: Lomond Therapeutics Holdings, Inc.

Sex: All

Age: 18+

Code: NCT06708897

Phase 1, Recruiting
Active & Responsive

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

for
Breast Cancer, Endometrial Cancer, Ovarian Cancer,
Location: Boston MA, Fairfax VA, Orlando FL, Cleveland OH,
Sponsor: Terremoto Biosciences Inc.

Sex: All

Age: 18+

Code: NCT07109726

Phase 1, Phase 2, Recruiting
Active & Responsive

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

for
Neuroblastoma, Rhabdomyosarcoma, Synovial Sarcoma,
Location: Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 0 - 25

Code: NCT06625190

Phase 1, Phase 2, Recruiting
Active & Responsive

Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia

for
Chronic Myelomonocytic Leukemia, Myelodysplastic Syndromes,
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18 - 70+

Code: NCT07071155

Early Phase 1, Recruiting

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Active & Responsive

A First-in-Human Study to Evaluate Implantable Iontophoresis Chemotherapy Delivery Device With Gemcitabine Once Weekly or Twice Weekly in Participants With Pancreatic Cancer

for
Pancreatic Adenocarcinoma Non-resectable
Location: Morgantown WV, Ann Arbor MI
Sponsor: Continuity Biosciences, LLC

Sex: All

Age: 18+

Code: NCT07481383

Phase 1, Recruiting
Active & Responsive

Use of [18F] Fluoroethyl-L-tyrosine PET/MRI for Identifying Small Functional Pituitary Adenomas

for
Pituitary Adenoma
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18 - 70+

Code: NCT07456878

Phase 1, Recruiting
Active & Responsive

Study to Identify Biomarkers of Oral Cavity Cancer Response to Neoadjuvant Immunotherapy Prior to Definitive Surgery

for
Oral Cavity Cancer
Location: Madison WI
Sponsor: University of Wisconsin, Madison

Sex: All

Age: 18+

Code: NCT07343596

Recruiting
Active & Responsive

Tegavivint With Gemcitabine in Patients With Relapsed or Refractory Osteosarcoma

for
Osteosarcoma Recurrent, Osteosarcoma in Children,
Location: Atlanta GA, Houston TX
Sponsor: Emory University

Sex: All

Age: 1 - 30

Code: NCT07144254

Phase 1, Recruiting
Active & Responsive

Feasibility Trial of Combination of Obstetrical Carrier Screening and Hereditary Cancer Screening

for
Hereditary Cancer Syndrome
Location: New York NY
Sponsor: Columbia University

Sex: Female

Age: 18 - 55

Code: NCT07195071

Recruiting
Active & Responsive

Feasibility Study for the SIRA-1000, SIRA® RFA Electrosurgical Device as an Adjunct to Breast Conserving Surgery

for
Breast Cancer, Breast-conserving Surgery,
Location: Galveston TX
Sponsor: Innoblative Designs, Inc.

Sex: Female

Age: 50+

Code: NCT07206121

Recruiting
Active & Responsive

Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)

for
Colon and Rectal Cancer
Location: New York NY
Sponsor: Columbia University

Sex: All

Age: 18+

Code: NCT07433673

Phase 2, Recruiting
Active & Responsive

Using Microbiome to Predict Durvalumab Toxicity in Post- Concurrent Chemoradiation Therapy (CCRT) NSCLC Patients

for
NSCLC, Stage III, Locally Advanced Lung Carcinoma
Location: Kansas City KS
Sponsor: Jun Zhang, MD, PhD

Sex: All

Age: 18+

Code: NCT04680377

Recruiting
Active & Responsive

Phase 1 Trial of D2C7-IT in Combination With 2141-V11 for Recurrent Malignant Glioma

for
Glioma, Malignant
Location: Durham NC
Sponsor: Darell Bigner

Sex: All

Age: 18+

Code: NCT04547777

Phase 1, Recruiting
Active & Responsive

A Phase 1a/1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia

for
Chronic Myeloid Leukemia,
Location: The Bronx NY, New York NY, Toronto, Houston TX,
Sponsor: Enliven Therapeutics

Sex: All

Age: 18+

Code: NCT05304377

Phase 1, Recruiting
Active & Responsive

Pembrolizumab and Pemetrexed for Progressive Chordoma

for
Chordomas, Chordoma
Location: Santa Monica CA
Sponsor: Saint John's Cancer Institute

Sex: All

Age: 18+

Code: NCT06794645

Phase 2, Recruiting
Active & Responsive

CAR T Cells After Lymphodepletion for the Treatment of IL13Rα2 Positive Recurrent or Refractory Brain Tumors in Children

for
Malignant Brain Neoplasm, Recurrent Malignant Brain Neoplasm,
Location: Ann Arbor MI, Duarte CA, Los Angeles CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 4 - 25

Code: NCT04510051

Phase 1, Recruiting
Active & Responsive

Durvalumab and Tremelimumab in Combination With Chemotherapy in HIV-infected Patients With Non-small Cell Lung Cancer

for
Carcinoma, Non-Small Cell Lung
Location: Baltimore MD, Washington D.C. DC
Sponsor: Georgetown University

Sex: All

Age: 18+

Code: NCT04499053

Phase 2, Recruiting
Active & Responsive

Customized TULSA-PRO Ablation Registry

for
Prostate Cancer, Prostate Adenocarcinoma,
Location: York PA, Jacksonville FL, Dallas TX, San Antonio TX,
Sponsor: Profound Medical Inc.

Sex: Male

Age: 18+

Code: NCT05001477

Recruiting
Active & Responsive

Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer

for
Breast Cancer
Location: Boston MA, Summit NJ
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT05950945

Phase 3, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer