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Oncology Clinical Trials

Browse 8,120 oncology clinical trials enrolling across the United States and Canada. 214 people applied to oncology studies last month. Search by city or state to find one near you.

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Active & Responsive

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

for
PIK3CA Mutation, HER2- Negative Breast Cancer,
Location: Boston MA, New Haven CT, New York NY, Hackensack NJ,
Sponsor: Relay Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06982521

Phase 3, Recruiting
Active & Responsive

Increasing Germline Genetic Testing for Patients With Cancer

for
Hereditary Pancreatic Cancer, Conditions or Focus of Study,
Location: Danville PA, Durham NC, Salisbury NC, Orlando FL,
Sponsor: Josh Peterson

Sex: All

Age: 0+

Code: NCT07307664

Recruiting
Active & Responsive

The Ailliance Post-Market Clinical Study

for
Spinal Deformity, Spinal Degenerative Disorder,
Location: Providence RI, New Brunswick NJ, Baltimore MD,
Sponsor: Medtronic Spinal and Biologics

Sex: All

Age: 18+

Code: NCT05856370

Recruiting
Active & Responsive

Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study

for
Prostate Carcinoma
Location: Boston MA, Philadelphia PA, Chicago IL, Seattle WA,
Sponsor: University of Washington

Sex: Male

Age: 40+

Code: NCT04472338

Recruiting
Active & Responsive

Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers

for
Cigarette Smoking-Related Carcinoma
Location: Washington D.C. DC, Buffalo NY, Tucson AZ
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05121051

Phase 2, Recruiting

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Active & Responsive

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

for
Rare Disorders, Undiagnosed Disorders,
Location: Sioux Falls SD
Sponsor: Sanford Health

Sex: All

Age: 0+

Code: NCT01793168

Recruiting
Active & Responsive

Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

for
Breast Cancer Screening, Breast Carcinoma in Situ,
Location: New York NY, Miami FL, Birmingham AL, Chicago IL,
Sponsor: University of California, San Francisco

Sex: Female

Age: 30 - 70+

Code: NCT02620852

Recruiting
Active & Responsive

Pediatric Normative Markerless Movement Analysis

for
Pediatric ALL, Adolescent
Location: Puyallup WA
Sponsor: MultiCare Health System Research Institute

Sex: All

Age: 3 - 25

Code: NCT06249880

Recruiting
Active & ResponsiveNew

AMC 120, Glofitamab Plus Chemoimmunotherapy in Newly Diagnosed HIV-Associated Large B-Cell Lymphoma (The "Glofit-RCHOP Study")

for
AIDS-Related Diffuse Large B-cell Lymphoma,
Location: Rockville MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT07649304

Phase 1, Recruiting
Active & ResponsiveNew

A Study of DS-3939a in Participants With Solid Tumors

for
Solid Tumor, Locally Advanced Non-Small Cell Lung Cancer,
Location: Fayetteville AR
Sponsor: Daiichi Sankyo

Sex: All

Age: 18+

Code: NCT07739966

Phase 1, Phase 2, Recruiting
Active & ResponsiveNew

First in Human Study of SNV1521 With a RAS Inhibitor for People With Advanced Pancreatic Cancer

for
Pancreatic Cancer, Pancreatic Acinar Carcinoma
Location: Houston TX
Sponsor: ParVation Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT07756281

Phase 1, Recruiting
Active & ResponsiveNew

Phase 1 Study of STRO-006 in Adults With Refractory Solid Tumors That Are Recurrent or Metastatic

for
Head & Neck Squamous Cell Carcinoma, Non-Small Cell Lung Cancer,
Location: Fairfax VA, Orlando FL, Irving TX
Sponsor: Sutro Biopharma, Inc.

Sex: All

Age: 18+

Code: NCT07807345

Phase 1, Recruiting
Active & ResponsiveNew

Single FrAction Interstitial BreaSt BracHytherApy

for
Breast Cancer
Location: Richmond VA
Sponsor: Virginia Commonwealth University

Sex: Female

Age: 40 - 70+

Code: NCT07654257

Phase 2, Recruiting
Active & ResponsiveNew

BRain-AVOidant Proton Craniospinal Irradiation for Leptomeningeal Metastases From Solid Tumor Malignancies

for
Leptomeningeal Metastasis, Breast Cancer, Lung Cancer (NSCLC)
Location: Miami FL
Sponsor: University of Miami

Sex: All

Age: 18+

Code: NCT07789912

Recruiting
Active & ResponsiveNew

EXercise-induced PhysioLogical Adaptations In Neurological Disorders

for
Epilepsy, Functional Neurological Disorder,
Location: Boston MA
Sponsor: Brigham and Women's Hospital

Sex: All

Age: 18+

Code: NCT07883720

Recruiting
Active & ResponsiveNew

Histotripsy in Biliary Tract Cancer

for
Biliary Track Cancer
Location: New York NY
Sponsor: NYU Langone Health

Sex: All

Age: 18+

Code: NCT07853690

Recruiting
Active & ResponsiveNew

Axelopran and Nivolumab in PD-1-Refractory Metastatic Melanoma

for
Unresectable Cutaneous Melanoma
Location: Pittsburgh PA
Sponsor: John Kirkwood

Sex: All

Age: 18+

Code: NCT07631325

Phase 1, Phase 2, Recruiting
Active & ResponsiveNew

Consolidative Metastasis and Primary Directed Therapy (MPDT) for Renal Cell Carcinoma (RCC)

for
Renal Cell Carcinoma
Location: Philadelphia PA
Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All

Age: 18+

Code: NCT06770855

Recruiting
Active & ResponsiveNew

Blood-Brain Barrier Disruption Using Exablate Magnetic Resonance-Guided Low Intensity Focused Ultrasound With Microbubbles in Combination With T-Cell Infusion in Patients With Newly Diagnosed Diffuse Midline Glioma (LIFT)

for
DMG, DIPG
Location: Washington D.C. DC
Sponsor: Children's National Research Institute

Sex: All

Age: 3 - 25

Code: NCT07796061

Phase 1, Recruiting
Active & ResponsiveNew

CCR2 PET Imaging Head and Neck Squamous Cell Carcinoma

for
Head and Neck Squamous Cell Carcinoma,
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT07659678

Phase 2, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer