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Oncology Clinical Trials

Browse 8,977 oncology clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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Active & Responsive

CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

for
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia,
Location: Boston MA, Atlanta GA, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18 - 70+

Code: NCT06059391

Phase2, Recruiting
Active & Responsive

The Cancer of the Pancreas Screening-5 CAPS5)Study

for
Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation,
Location: Boston MA, New Haven CT, New York NY, Philadelphia PA,
Sponsor: Johns Hopkins University

Sex: All

Age: 18+

Code: NCT02000089

Phase3, Recruiting
Active & Responsive

Screening Women With Prior HPV for Anal Neoplasia

for
HPV-related Lower Genital Tract Neoplasias,
Location: New York NY, Charleston SC, Houston TX
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: Female

Age: 35+

Code: NCT05217940

Recruiting
Active & Responsive

Study of 18F-FFNP Breast PET/MRI

for
Breast Cancer
Location: Madison WI
Sponsor: University of Wisconsin, Madison

Sex: Female

Age: 18+

Code: NCT06086704

Phase2, Recruiting
Active & Responsive

Predicting Response to Neoadjuvant Endocrine Therapy (Neo-PREDICT)

for
Breast Cancer Stage I, Breast Cancer Stage II,
Location: Washington D.C. DC
Sponsor: George Washington University

Sex: All

Age: 21+

Code: NCT06806930

Phase2, Recruiting

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Active & Responsive

Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience Research

for
Malignant Central Nervous System Neoplasm
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06117930

Recruiting
Active & Responsive

Sirolimus in Combination With Metronomic Chemotherapy in Children With High-Risk Solid Tumors

for
Solid Tumor
Location: Pittsburgh PA, Atlanta GA, St Louis MO, Houston TX
Sponsor: Emory University

Sex: All

Age: 1 - 30

Code: NCT04469530

Phase2, Recruiting
Active & Responsive

Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung Cancer

for
Advanced Lung Adenocarcinoma, Refractory Lung Adenocarcinoma,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT06495125

Phase2, Recruiting
Active & Responsive

Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions

for
Pheochromocytoma, Paraganglioma, Inherited Cancer Syndrome,
Location: San Antonio TX
Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All

Age: 0+

Code: NCT03160274

Recruiting
Active & Responsive

Study of Screening Brain MRIs in Stage IV Breast Cancer

for
Triple Negative Breast Cancer, HER2-positive Breast Cancer,
Location: Clearwater FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT05115474

Phase2, Recruiting
Active & Responsive

CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer

for
Gastric Cancer, Esophageal Cancer, Stomach Cancer,
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT05187182

Phase1, Recruiting
Active & Responsive

The Role of MicroRNA in the Diagnosis, Prognosis and Response to Treatment in Pancreatic Cancer

for
Pancreatic Cancer Stage III, Pancreatic Cancer Stage IV,
Location: Norwalk CT
Sponsor: Nuvance Health

Sex: All

Age: 18+

Code: NCT04406831

Recruiting
Active & Responsive

Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001

for
Rectal Cancer
Location: Lexington KY, Omaha NE, San Antonio TX
Sponsor: University of Nebraska

Sex: All

Age: 18+

Code: NCT05254327

Phase2, Recruiting
Active & Responsive

Multicenter Clinical Trial of ST-02 for Ablation of Upper Tract Urothelial Carcinoma

for
Urothelial Carcinoma of the Renal Pelvis and Ureter,
Location: Halifax, Montreal, Toronto, London, Winnipeg, Vancouver
Sponsor: Peter Black

Sex: All

Age: 18+

Code: NCT06124976

Phase2, Phase3, Recruiting
Active & Responsive

Unidos Contra el VPH

for
Human Papilloma Virus (HPV), Cervical Cancers
Location: El Paso TX
Sponsor: University of Texas at Austin

Sex: Female

Age: 30 - 65

Code: NCT06825689

Recruiting
Active & Responsive

Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation

for
CNS Embryonal Tumor, CNS, Medulloblastoma,
Location: Quebec, Sherbrooke, Montreal, Toronto, Hamilton, London,
Sponsor: C17 Council

Sex: All

Age: 0 - 6

Code: NCT06942039

Early_phase1, Recruiting
Active & Responsive

Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors

for
Somatostatin Receptor Positive, NETs, Lymphoma, Solid Tumor,
Location: Philadelphia PA, Houston TX, San Francisco CA
Sponsor: ITM Solucin GmbH

Sex: All

Age: 2 - 18

Code: NCT06441331

Phase1, Recruiting
Active & Responsive

A Blended e-Health Intervention to Improve Fear of Progression in Women With Gynecologic or Breast Cancer

for
Anatomic Stage I Breast Cancer AJCC v8,
Location: Upland CA, Irvine CA, Lancaster CA, Duarte CA,
Sponsor: City of Hope Medical Center

Sex: Female

Age: 18+

Code: NCT07741968

Recruiting
Active & Responsive

A PET Imaging Agent (64Cu-DOTA-Pembrolizumab) for Determining Treatment Response Among Patients With Stage IV Non-small Cell Lung Cancer Receiving Pembrolizumab

for
Metastatic Lung Non-Small Cell Carcinoma,
Location: Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 18+

Code: NCT07619599

Phase1, Recruiting
Active & Responsive

Study of Oral MRT-2359 With Apalutamide in Prostate Cancer

for
Castration-Resistant Prostate Cancer (CRPC),
Location: East Brunswick NJ, Omaha NE, West Valley City UT,
Sponsor: Monte Rosa Therapeutics, Inc

Sex: Male

Age: 18+

Code: NCT07745361

Phase2, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer