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Oncology Clinical Trials

Browse 8,977 oncology clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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Active & Responsive

Extending Prostate Genetic Awareness, Navigation, and Delivery: The EXPAND Network

for
Metastatic Prostate Carcinoma,
Location: Philadelphia PA
Sponsor: Thomas Jefferson University

Sex: Male

Age: 18+

Code: NCT05627219

Recruiting
Active & Responsive

Study of Pembrolizumab, Carboplatin, Paclitaxel, and Radiation for the Treatment of Early-Stage Anal Cancer

for
Anal Cancer
Location: New Brunswick NJ, Baltimore MD, Indianapolis IN,
Sponsor: Dustin Deming

Sex: All

Age: 18+

Code: NCT06493019

Phase2, Recruiting
Active & Responsive

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

for
Solid Tumor, Adult, Colorectal Cancer,
Location: New York NY, Jacksonville FL, Tampa FL, Columbus OH,
Sponsor: A2 Biotherapeutics Inc.

Sex: All

Age: 18+

Code: NCT04981119

Recruiting
Active & Responsive

Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors

for
Solid Tumor
Location: Canton OH, Cleveland OH
Sponsor: Lamassu Bio Inc

Sex: All

Age: 18+

Code: NCT06578624

Phase1, Phase2, Recruiting
Active & Responsive

Magnetic Resonance (MR) Imaging With Hyperpolarized 13C-Pyruvate +/- 13C,15N-Urea in Patients With Prostate Cancer

for
Prostate Cancer
Location: San Francisco CA
Sponsor: Robert Bok, MD, PhD

Sex: Male

Age: 18+

Code: NCT06391034

Phase2, Recruiting

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Active & Responsive

First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

for
Non-Small Cell Lung Cancer, NSCLC,
Location: Philadelphia PA, Fairfax VA, Charlotte NC, Nashville TN,
Sponsor: Pierre Fabre Medicament

Sex: All

Age: 18+

Code: NCT06043817

Phase1, Phase2, Recruiting
Active & Responsive

ASCVD Management Using CCTA in Prostate Cancer Patients on ADT

for
Prostate Cancer
Location: Indianapolis IN, Carmel IN
Sponsor: Indiana University

Sex: Male

Age: 40+

Code: NCT05879913

Recruiting
Active & Responsive

HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia

for
Human Papillomavirus Type 16,
Location: Baltimore MD, Birmingham AL
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: Female

Age: 19+

Code: NCT04131413

Phase1, Recruiting
Active & Responsive

A Study of NovoTTF-200T(P) in Combination With Gemcitabine and Nab-Paclitaxel for Resectable Pancreatic Adenocarcinoma

for
Pancreatic Adenocarcinoma, Resectable Pancreatic Cancer
Location: Columbus OH
Sponsor: Ashish Manne

Sex: All

Age: 18+

Code: NCT05624918

Phase2, Recruiting
Active & Responsive

Enfortumab Vedotin for the Treatment of Patients With Metastatic or Unresectable Squamous Cell Carcinoma of the Penis

for
Metastatic Penile Squamous Cell Carcinoma,
Location: Jacksonville FL, Rochester MN, Phoenix AZ
Sponsor: Mayo Clinic

Sex: Male

Age: 18+

Code: NCT06104618

Phase2, Recruiting
Active & Responsive

A Phase 1/2 Study of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Advanced or Metastatic Solid Tumors

for
Metastatic Hepatocellular Carcinoma,
Location: New York NY, Pittsburgh PA, Nashville TN, Zion IL,
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT06427941

Phase1, Phase2, Recruiting
Active & Responsive

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

for
Hematologic Malignancy, Acute Leukemia, Remission,
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 0 - 60

Code: NCT05735717

Phase2, Recruiting
Active & Responsive

Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors

for
Central Nervous System Tumor, Diffuse Intrinsic Pontine Glioma,
Location: Seattle WA
Sponsor: Seattle Children's Hospital

Sex: All

Age: 1 - 26

Code: NCT04185038

Phase1, Recruiting
Active & Responsive

ZEN003694 and Enzalutamide Versus Enzalutamide Monotherapy in Metastatic Castration-Resistant Prostate Cancer

for
Metastatic Castration-Resistant Prostate Cancer
Location: Columbia MD, Fairfax VA, Margate FL, Plantation FL,
Sponsor: Zenith Epigenetics

Sex: Male

Age: 18+

Code: NCT04986423

Phase2, Recruiting
Active & Responsive

Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

for
Breast Neoplasms, Brain Neoplasms, Neoplasms by Site, Neoplasms,
Location: Boston MA, Norfolk VA, Detroit MI, Centerville OH,
Sponsor: Stemline Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05386108

Phase1, Phase2, Recruiting
Active & Responsive

A Study to Assess a New Medicine Called IPN01195 When Administered Alone in Adults With Advanced Solid Tumours

for
Advanced Solid Tumor
Location: Fairfax VA, Grand Rapids MI, Nashville TN, Dallas TX,
Sponsor: Ipsen

Sex: All

Age: 18+

Code: NCT06833008

Phase1, Phase2, Recruiting
Active & Responsive

A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)

for
Non-Muscle Invasive Bladder Cancer
Location: Sherbrooke, Baltimore MD, Toronto, Tampa FL, Chicago IL,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06637423

Phase1, Phase2, Recruiting
Active & Responsive

Pilot Study for Colorectal Cancer and Advanced Adenoma Detection With the Mainz Biomed Colorectal Cancer Test

for
Colorectal Cancer Screening, Colorectal Cancer Metastatic,
Location: Morrisville NC
Sponsor: Mainz Biomed

Sex: All

Age: 18+

Code: NCT06864338

Recruiting
Active & Responsive

Reiki Breast Surgery QOL Project for Women Undergoing Breast Surgery

for
Breast Cancer
Location: The Bronx NY
Sponsor: Albert Einstein College of Medicine

Sex: Female

Age: 18 - 70+

Code: NCT06524895

Recruiting
Active & Responsive

Mutant KRAS -Targeted Long Peptide Vaccine for Patients at High Risk of Developing Pancreatic Cancer

for
High Risk Cancer, Pancreatic Cancer
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 40+

Code: NCT05013216

Phase1, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer