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Oncology Clinical Trials

Browse 8,120 oncology clinical trials enrolling across the United States and Canada. 215 people applied to oncology studies last month. Search by city or state to find one near you.

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Active & Responsive

Study of Human Brain-Gut Axis and Gut Microbiome in Patients With Brain Lesions - Repository for Neuroscience Research

for
Malignant Central Nervous System Neoplasm
Location: Jacksonville FL
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06117930

Recruiting
Active & Responsive

Sirolimus in Combination With Metronomic Chemotherapy in Children With High-Risk Solid Tumors

for
Solid Tumor
Location: Pittsburgh PA, Atlanta GA, St Louis MO, Houston TX
Sponsor: Emory University

Sex: All

Age: 1 - 30

Code: NCT04469530

Phase 2, Recruiting
Active & Responsive

Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders

for
Neurodevelopmental Disorders, Autism, Autism Spectrum Disorder,
Location: Kingston, Toronto, Hamilton, London, Edmonton, Calgary
Sponsor: Holland Bloorview Kids Rehabilitation Hospital

Sex: All

Age: 8 - 17

Code: NCT06081348

Phase 2, Recruiting
Active & Responsive

Nivolumab Alone or Plus Relatlimab or Ipilimumab for Patients With Locally-Advanced Unresectable or Metastatic Basal Cell Carcinoma

for
Basal Cell Carcinoma
Location: Baltimore MD
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All

Age: 18+

Code: NCT03521830

Phase 2, Recruiting
Active & Responsive

Defactinib, Avutometinib and Nivolumab for the Treatment of Anti-PD1 Refractory LKB1-Mutant Advanced Non-Small Cell Lung Cancer

for
Advanced Lung Adenocarcinoma, Refractory Lung Adenocarcinoma,
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18+

Code: NCT06495125

Phase 2, Recruiting

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Active & Responsive

Acolbifene Versus Low Dose Tamoxifen for the Prevention of Breast Cancer in Premenopausal Women at High Risk for Development of Breast Cancer

for
Breast Atypical Hyperplasia, Breast Carcinoma,
Location: Columbus OH, Chicago IL, Kansas City KS, Duarte CA
Sponsor: National Cancer Institute (NCI)

Sex: Female

Age: 35+

Code: NCT05941520

Phase 2, Recruiting
Active & Responsive

Study of Screening Brain MRIs in Stage IV Breast Cancer

for
Triple Negative Breast Cancer, HER2-positive Breast Cancer,
Location: Clearwater FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT05115474

Phase 2, Recruiting
Active & Responsive

In Vivo Liquid Biopsy of Melanoma (Cytophone)

for
Melanoma, Circulating Tumor Cells, Metastatic Melanoma,
Location: Madison WI
Sponsor: Cytoastra

Sex: All

Age: 18 - 70+

Code: NCT06488365

Recruiting
Active & Responsive

CA-4948 in Combination With FOLFOX/PD-1 Inhibitor +/- Trastuzumab for Untreated Unresectable Gastric and Esophageal Cancer

for
Gastric Cancer, Esophageal Cancer, Stomach Cancer,
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT05187182

Phase 1, Recruiting
Active & Responsive

Rare Embryonal Tumors of the Central Nervous System: International Registry

for
Embryonal Tumor
Location: Ottawa
Sponsor: Immune Oncology Research Institute

Sex: All

Age: 0 - 25

Code: NCT05711992

Recruiting
Active & Responsive

The Role of MicroRNA in the Diagnosis, Prognosis and Response to Treatment in Pancreatic Cancer

for
Pancreatic Cancer Stage III, Pancreatic Cancer Stage IV,
Location: Norwalk CT
Sponsor: Nuvance Health

Sex: All

Age: 18+

Code: NCT04406831

Recruiting
Active & Responsive

Non-Endoscopic Detection of Barrett's Esophagus Using Methylation Biomarkers on EndoSign® Cell Collection Device Samples

for
Barrett Esophagus
Location: Cordova TN
Sponsor: Cyted Health Inc

Sex: All

Age: 18+

Code: NCT06803927

Recruiting
Active & Responsive

Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001

for
Rectal Cancer
Location: Lexington KY, Omaha NE, San Antonio TX
Sponsor: University of Nebraska

Sex: All

Age: 18+

Code: NCT05254327

Phase 2, Recruiting
Active & Responsive

Identifying Findings on Brain Scans That Could Help Make Better Predictions About Brain Cancer Progression, The GABLE Trial

for
Glioblastoma, IDH-Wildtype
Location: Durham NC, Winston-Salem NC, Morgantown WV,
Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All

Age: 18+

Code: NCT06319027

Phase 2, Recruiting
Active & Responsive

Multicenter Clinical Trial of ST-02 for Ablation of Upper Tract Urothelial Carcinoma

for
Urothelial Carcinoma of the Renal Pelvis and Ureter,
Location: Halifax, Montreal, Toronto, London, Winnipeg, Vancouver
Sponsor: Peter Black

Sex: All

Age: 18+

Code: NCT06124976

Phase 2, Phase 3, Recruiting
Active & Responsive

Unidos Contra el VPH

for
Human Papilloma Virus (HPV), Cervical Cancers
Location: El Paso TX
Sponsor: University of Texas at Austin

Sex: Female

Age: 30 - 65

Code: NCT06825689

Recruiting
Active & Responsive

Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

for
Oropharyngeal Squamous Cell Carcinoma, Carcinoma, Squamous Cell,
Location: Chapel Hill NC, North Charleston SC
Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All

Age: 18+

Code: NCT04564989

Recruiting
Active & Responsive

Evaluation of RBS2418 in Combination With Tremelimumab Plus Durvalumab in Participants With Advanced Unresectable Hepatocellular Carcinoma

for
Advanced Unresectable Hepatocellular Carcinoma
Location: Baltimore MD, Nashville TN, Dallas TX, Fort Worth TX
Sponsor: Riboscience, LLC.

Sex: All

Age: 18+

Code: NCT07175441

Phase 2, Recruiting
Active & Responsive

Autonomic and Renal Contributions to Hypertension With ADT

for
Androgen Deprivation Therapy, Prostate Cancer, Hypertension,
Location: Richmond VA
Sponsor: Virginia Commonwealth University

Sex: Male

Age: 40+

Code: NCT07848828

Phase 4, Recruiting
Active & Responsive

[18F]FTT Positron Emission Tomography/Computed Tomography to Predict Treatment Response in Patients Scheduled to Receive Gemcitabine, Cisplatin, and Durvalumab for Newly Diagnosed Cholangiocarcinoma

for
Cholangiocarcinoma
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 18+

Code: NCT07673341

Phase 2, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer