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Oncology Clinical Trials

Browse 8,977 oncology clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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Active & Responsive

Evaluation of Early Identification of Cognitive Side Effects of Immunotherapy

for
Hematopoietic and Lymphatic System Neoplasm,
Location: Minneapolis MN
Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All

Age: 18+

Code: NCT06414278

Recruiting
Active & Responsive

A Clinical Trial to Test if the Investigational Drug BNT329 is Safe and Potentially Beneficial for People With Advanced Solid Tumors Known to Express the Tumor Marker CA19-9

for
Advanced Solid Cancers
Location: New York NY, Orlando FL, Denver CO
Sponsor: BioNTech SE

Sex: All

Age: 18+

Code: NCT07186842

Phase1, Phase2, Recruiting
Active & Responsive

The Florida ASCENT Study

for
Cancer, Food Deprivation, Food Habits, Food Selection,
Location: Gainesville FL
Sponsor: University of Florida

Sex: All

Age: 18 - 70+

Code: NCT07042243

Recruiting
Active & Responsive

A Study to Assess the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic, Immunogenicity and Antitumour Activity of IPN60300 in Adults With Locally Advanced or Metastatic Solid Tumours

for
Locally Advanced Solid Tumor, Metastatic Solid Tumor
Location: New Haven CT, Philadelphia PA, Fairfax VA,
Sponsor: Ipsen

Sex: All

Age: 18+

Code: NCT07213817

Phase1, Phase2, Recruiting
Active & Responsive

KEYMAKER-U01 Substudy 01J: A Study of Pembrolizumab Plus MK-1084 in Participants With Non-Small Cell Lung Cancer (NSCLC) With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) G12C Mutations (MK-3475-01J/KEYMAKER-U01J)

for
Malignant Neoplasm
Location: Clermont FL, Fargo ND, Sioux Falls SD
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07252739

Phase2, Recruiting

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Active & Responsive

Head and Neck Cancer Study Project in the Geriatric Population

for
Head and Neck Neoplasms
Location: Providence RI
Sponsor: Brown University

Sex: All

Age: 65+

Code: NCT06998069

Phase3, Recruiting
Active & Responsive

A Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Anti-tumour Activity of IPN01203 in Adults With Locally Advanced or Metastatic Solid Tumours Exposed to Immune Checkpoint Inhibitor Therapies

for
Advanced Solid Tumor, Metastatic Solid Tumor
Location: Toronto, Grand Rapids MI, Nashville TN, Houston TX,
Sponsor: Ipsen

Sex: All

Age: 18+

Code: NCT07213830

Phase1, Phase2, Recruiting
Active & Responsive

Use of a Decision Aid to Resolve Uncertainty About Radioactive Iodine Treatment in Patients With Intermediate Risk Thyroid Cancer

for
Thyroid Cancer
Location: Washington D.C. DC, Falls Church VA
Sponsor: Georgetown University

Sex: All

Age: 18+

Code: NCT06980103

Recruiting
Active & Responsive

Efficacy and Safety of a Single Dose of LS301-IT for Fluorescence Intraoperative Molecular Imaging (IMI) for Patients Undergoing Lung Cancer Resection for Non Small Cell Lung Cancer

for
Non Small Cell Lung Cancer (NSCLC)
Location: Philadelphia PA, Dallas TX
Sponsor: Integro Theranostics

Sex: All

Age: 18+

Code: NCT07276789

Phase2, Recruiting
Active & Responsive

Trial of pTVG-HP+Nivo+Targeted Ablation of Resistant Lesions in Non-Castrate RecurrentOMPC

for
Prostate Cancer Patients, Non-castrate Prostate Cancer,
Location: Madison WI
Sponsor: University of Wisconsin, Madison

Sex: Male

Age: 18+

Code: NCT07090148

Phase1, Recruiting
Active & Responsive

The Sarah Nanotechnology System for Treatment of Advanced Metastatic Solid Tumors Using Hyperthermia.

for
Metastatic Solid Tumors, Stage 4 Cancer
Location: Rochester MN
Sponsor: New Phase Ltd.

Sex: All

Age: 18+

Code: NCT07224464

Recruiting
Active & Responsive

Intraoperative Fluorescence-Guided Aspirate Tissue Monitoring of 5-ALA During Brain Tumor Surgery

for
Brain Neoplasms
Location: Chicago IL
Sponsor: University of Illinois at Chicago

Sex: All

Age: 18 - 70+

Code: NCT07111182

Recruiting
Active & Responsive

Evaluation of the Safety, Efficacy, and Pharmacokinetics of NBM-BMX in Patients With Metastatic Uveal Melanoma

for
Metastatic Uveal Melanoma, Uveal Melanoma, Metastatic,
Location: Nashville TN, Denver CO, Scottsdale AZ
Sponsor: Novelwise Pharmaceutical Corporation

Sex: All

Age: 18+

Code: NCT07136181

Phase1, Phase2, Recruiting
Active & Responsive

Maintenance Zanzalintinib With Etoposide After HDCT in GCT

for
Germ Cell Tumor
Location: Indianapolis IN
Sponsor: Indiana University

Sex: All

Age: 18+

Code: NCT06937866

Phase1, Phase2, Recruiting
Active & Responsive

DPYD Pharmacogenomics and Fluoropyrimidine (FP) Dose-Adjustment

for
Colorectal Neoplasms, Breast Neoplasms, Head and Neck Neoplasms,
Location: Toms River NJ, Jersey City NJ, Belleville NJ, Newark NJ,
Sponsor: Rutgers, The State University of New Jersey

Sex: All

Age: 18+

Code: NCT07158164

Recruiting
Active & Responsive

Neoadjuvant Darolutamide Alone or in Combination With Standard Therapy for Stage II-IIIA, AR+, TNBC

for
Anatomic Stage II Breast Cancer AJCC v8,
Location: Nashville TN
Sponsor: Vandana Abramson

Sex: All

Age: 18+

Code: NCT07016399

Phase2, Recruiting
Active & Responsive

NeoCARD: Anthracycline-Free Neoadjuvant Chemoimmunotherapy in Triple-Negative Breast Cancer Patients

for
Triple Negative Breast Cancer
Location: Charleston SC
Sponsor: Medical University of South Carolina

Sex: All

Age: 18+

Code: NCT06845319

Phase2, Recruiting
Active & Responsive

Surviving Daily Life

for
Stress, Cognitive Change, Breast Cancer, Breast Carcinoma,
Location: Philadelphia PA
Sponsor: Thomas Jefferson University

Sex: Female

Age: 40+

Code: NCT07054723

Recruiting
Active & Responsive

A Clinical Trial to Test if an Investigational Combination Therapy With BNT326 and BNT327 is Safe and Potentially Beneficial for People With Advanced Non-small Cell Lung Cancer (NSCLC)

for
Non-small Cell Lung Cancer
Location: Boston MA, New Haven CT, New York NY,
Sponsor: BioNTech SE

Sex: All

Age: 18+

Code: NCT07111520

Phase1, Phase2, Recruiting
Active & Responsive

Phase 1/2 Dose Finding, Safety and PK Study in Advanced Refractory Solid Tumors

for
Prostate Cancer Castration-resistant Prostate Cancer,
Location: East Brunswick NJ, Fairfax VA, Grand Rapids MI,
Sponsor: MBrace Therapeutics

Sex: All

Age: 18+

Code: NCT07145255

Phase1, Phase2, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer