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Oncology Clinical Trials

Browse 9,028 oncology clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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Study of FIH of STX-241 in Locally Advanced or Metastatic NSCLC Resistant to EGFR TKIs

for
Non-small Cell Lung Cancer (NSCLC)
Location: Nashville TN, Houston TX
Sponsor: Pierre Fabre Medicament

Sex: All

Age: 18+

Code: NCT06567015

Phase1, Phase2, Recruiting

BAL0891 in Patients With Advanced Solid Tumors or Relapsed or Refractory Acute Myeloid Leukemia

for
Advanced Solid Tumor, TNBC - Triple-Negative Breast Cancer,
Location: New Haven CT, New York NY, The Bronx NY,
Sponsor: SillaJen, Inc.

Sex: All

Age: 18+

Code: NCT05768932

Phase1, Recruiting

Avecure Flexible Microwave Ablation Probe For Lung Nodules

for
Stage I - II Primary Lung Cancer, Stage I Lung Cancer,
Location: Boston MA
Sponsor: Beth Israel Deaconess Medical Center

Sex: All

Age: 22+

Code: NCT05281237

Recruiting

Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers

for
Advanced Solid Tumor, Non Small Cell Lung Cancer,
Location: Boston MA, New Haven CT, Lake Success NY, New York NY,
Sponsor: Synthekine

Sex: All

Age: 18+

Code: NCT05098132

Phase1, Phase2, Recruiting

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

for
Non Small Cell Lung Cancer, Lung Cancer, Breast Cancer,
Location: Boston MA, New Haven CT, New York NY,
Sponsor: SystImmune Inc.

Sex: All

Age: 18+

Code: NCT05983432

Phase1, Recruiting

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TEMPUS ARIES: A Biobank Registry Platform Study in Oncology

for
Cancer
Location: Fairhaven MA, Norwich CT, York PA, East Syracuse NY,
Sponsor: Tempus AI

Sex: All

Age: 18 - 70+

Code: NCT06207032

Recruiting

Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies

for
Advanced Malignant Solid Neoplasm,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05039632

Phase1, Phase2, Recruiting

Study of ctDNA Guided Change in Tx for Refractory Minimal Residual Disease in Colon Adenocarcinomas

for
Colon Adenocarcinoma, Colorectal Cancer
Location: Orange CA
Sponsor: University of California, Irvine

Sex: All

Age: 18+

Code: NCT04920032

Phase1, Recruiting

PhI Pilot Study Pafolacianine Inject for Intraoperative Imaging on Outcomes of GI Cancer Peritoneal Carcinomatosis

for
Gastrointestinal Cancer, Peritoneal Carcinomatosis
Location: Orange CA
Sponsor: University of California, Irvine

Sex: All

Age: 18+

Code: NCT06511037

Early_phase1, Recruiting

Immune Profiling for Cancer Immunotherapy Response

for
Cancer, Tumor, Solid, Hematologic Malignancy, Blood Cancer
Location: Lebanon NH
Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All

Age: 18+

Code: NCT06116032

Recruiting

Investigating the Effectiveness of Stereotactic Body Radiotherapy (SBRT) in Addition to Standard of Care Treatment for Cancer That Has Spread Beyond the Original Site of Disease

for
Triple Negative Breast Cancer, Non Small Cell Lung Cancer,
Location: Hartford CT, Commack NY, Norwalk CT, Uniondale NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT03808337

Phase2, Recruiting

Tirzepatide for Weight Loss Intervention in Early-Stage Hormone Receptor Positive/HER2 Negative Breast Cancer

for
Hormone Receptor-Positive Breast Cancer,
Location: Long Branch NJ, Elizabeth NJ, Newark NJ, Livingston NJ,
Sponsor: Rutgers, The State University of New Jersey

Sex: All

Age: 18+

Code: NCT06518837

Phase2, Recruiting

Revumenib in Combination With 7+3 + Midostaurin in AML

for
Acute Myeloid Leukemia, AML, Adult, AML With Gene Mutations,
Location: Boston MA, New Haven CT
Sponsor: Richard Stone, MD

Sex: All

Age: 18 - 70+

Code: NCT06313437

Phase1, Recruiting

Neoadjuvant PD-1 Plus TIGIT Blockade in Patients With Cisplatin-Ineligible Operable High-Risk Urothelial Carcinoma

for
Metastatic Malignancy
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05394337

Phase1, Phase2, Recruiting

A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

for
Non Small Cell Lung Cancer
Location: Westbrook ME, Stony Brook NY, Stamford CT,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06312137

Phase3, Recruiting

Phase Ib Study of CBP-1019 in Combination With FOLFOX +/- Bevacizumab, Pembrolizumab, or Enzalutamide for Metastatic TRPV6-overexpressing Solid Tumors of Epithelial Origin

for
Solid Tumor
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06576037

Phase1, Recruiting

Study of HER2 Directed Dendritic Cell (DC1) Vaccine + Weekly Paclitaxel, Trastuzumab & Pertuzumab

for
HER2-positive Breast Cancer
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT05325632

Phase2, Recruiting

Group Cognitive Behavior Sessions (CBCSM) to Decrease Distress in Cancer Patients

for
Hematopoietic and Lymphoid System Neoplasm,
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06015932

Recruiting

Combination Therapy in Cancers With Mutations in DNA Repair Genes

for
Metastatic Solid Tumor, BRCA1 Mutation, BRCA2 Mutation,
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT05694715

Phase1, Recruiting

Azacitidine, Venetoclax, and Gilteritinib in Treating Patients With Recurrent/Refractory FLT3-Mutated Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, or High-Risk Myelodysplastic Syndrome/Myeloproliferative Neoplasm

for
Recurrent Acute Myeloid Leukemia,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04140487

Phase1, Phase2, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer