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Oncology Clinical Trials

Browse 8,120 oncology clinical trials enrolling across the United States and Canada. 218 people applied to oncology studies last month. Search by city or state to find one near you.

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Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer

for
Advanced Malignant Solid Neoplasm,
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 18+

Code: NCT04511039

Phase 1, Recruiting

A Trial of AMXI-5001 for Treatment in Patients With Advanced Malignancies

for
Advanced Malignant Neoplasm, Breast Cancer, Ovarian Cancer,
Location: Baltimore MD, Nashville TN, Houston TX, Los Angeles CA
Sponsor: AtlasMedx, Incorporated

Sex: All

Age: 18+

Code: NCT04503265

Phase 1, Phase 2, Recruiting

A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors

for
Cancer, Cancer, Lung
Location: Lebanon NH, Philadelphia PA, Fairfax VA, Toronto,
Sponsor: Conjupro Biotherapeutics, Inc.

Sex: All

Age: 18+

Code: NCT05948865

Phase 1, Recruiting

Telemedicine for Improvement of Care for Older Adults With Cancer in the Underserved Community, The GAIN-S Trial

for
Hematopoietic and Lymphoid System Neoplasm,
Location: Upland CA, Lancaster CA, Duarte CA
Sponsor: City of Hope Medical Center

Sex: All

Age: 65+

Code: NCT06022965

Recruiting

Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers

for
Metastatic Colorectal Carcinoma,
Location: The Bronx NY, New York NY, Pittsburgh PA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05803382

Phase 1, Recruiting

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Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

for
Anatomic Stage IV Breast Cancer AJCC v8,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04771520

Phase 2, Recruiting

Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study

for
Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma,
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 0+

Code: NCT06295965

Recruiting

CT-95 in Advanced Cancers Associated With Mesothelin Expression

for
Mesothelin-Expressing Tumors, Epithelial Ovarian Cancer,
Location: Hackensack NJ, Philadelphia PA, Grand Rapids MI,
Sponsor: Context Therapeutics Inc.

Sex: All

Age: 18+

Code: NCT06756035

Phase 1, Recruiting

A Phase 1 Study of LNCB74 in Advanced Solid Tumors

for
Ovarian Cancer, Breast Cancer, Endometrial Cancer,
Location: Boston MA, New York NY, Philadelphia PA,
Sponsor: LigaChem Biosciences, Inc.

Sex: All

Age: 18+

Code: NCT06774963

Phase 1, Recruiting

Community-Based Physical Activity Intervention for Underserved Cancer Survivors

for
Hematopoietic and Lymphoid System Neoplasm,
Location: Buffalo NY
Sponsor: Roswell Park Cancer Institute

Sex: All

Age: 18+

Code: NCT06206863

Recruiting

Study of GVV858 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

for
Advanced HR+/HER2- Breast Cancer,
Location: Toronto, Atlanta GA, Nashville TN, San Antonio TX
Sponsor: Novartis Pharmaceuticals

Sex: All

Age: 18+

Code: NCT07288359

Phase 1, Phase 2, Recruiting

Role of Ablative Radiotherapy in the Management of Metastatic Disease: A Patient Data Registry

for
Oligometastasis, Metastatic Cancer
Location: Raleigh NC, Cary NC, Durham NC
Sponsor: Duke University

Sex: All

Age: 18+

Code: NCT04085029

Recruiting

PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors

for
Refractory Solid Tumors, Relapsed Solid Tumors,
Location: Boston MA, Philadelphia PA, Houston TX,
Sponsor: Theodore Laetsch

Sex: All

Age: 1 - 30

Code: NCT06721689

Phase 1, Phase 2, Recruiting

A Study to Investigate Safety and Effectiveness of Tacabrutideg (BGB-16673) in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

for
B-cell Malignancy, Relapsed Cancer, Refractory Cancer,
Location: New York NY, Philadelphia PA, Rochester NY,
Sponsor: BeOne Medicines

Sex: All

Age: 18+

Code: NCT06634589

Phase 1, Phase 2, Recruiting

Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

for
Advanced Malignant Solid Neoplasm,
Location: New Haven CT, Trumbull CT, Bethesda MD, Pittsburgh PA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT05691491

Phase 1, Phase 2, Recruiting

Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors

for
High-grade Glioma, Solid Tumor, Unspecified, Child
Location: Edison NJ, Miami FL, Little Rock AR
Sponsor: Laminar Pharmaceuticals

Sex: All

Age: 0 - 18

Code: NCT04299191

Phase 1, Phase 2, Recruiting

A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

for
Triple Negative Breast Cancer, Diffuse Large B Cell Lymphoma,
Location: Fairfax VA, Pittsburgh PA, Canton OH, Columbus OH,
Sponsor: OncoNano Medicine, Inc.

Sex: All

Age: 18+

Code: NCT06022029

Phase 1, Recruiting

A Prospective, Single Blinded Study for Predicting Colon Polyp Histology With Narrow Band Imaging

for
Colonoscopy, Adenomatous Polyp, Neoplastic
Location: Kansas City MO
Sponsor: Midwest Biomedical Research Foundation

Sex: All

Age: 18+

Code: NCT00613262

Recruiting

Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases

for
Brain Metastases, Tumor
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT05064280

Phase 2, Recruiting

A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body

for
Melanoma, Clear-Cell Renal-Cell Carcinoma (ccRCC),
Location: North Haven CT, Lake Success NY, Chapel Hill NC,
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT06413680

Phase 1, Phase 2, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer