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Oncology Clinical Trials

Browse 8,894 oncology clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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Phase II Study of Olaparib and Pembrolizumab in Advanced Melanoma With Homologous Recombination (HR) Mutation

for
Metastatic Melanoma
Location: Houston TX, San Francisco CA
Sponsor: California Pacific Medical Center Research Institute

Sex: All

Age: 18+

Code: NCT04633902

Phase2, Recruiting
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Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)

for
Chronic Lymphocytic Leukemia (CLL)
Location: Boston MA, Hackensack NJ, Philadelphia PA,
Sponsor: AbbVie

Sex: All

Age: 18+

Code: NCT04895436

Phase2, Recruiting

A Study Comparing Personalized Radiation Therapy With Standard Radiation Therapy in People With HPV-Positive Throat Cancer

for
HPV-Related Squamous Cell Carcinoma
Location: Hartford CT, Commack NY, Uniondale NY, Harrison NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06563479

Phase3, Recruiting

Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma

for
Pancreatic Ductal Adenocarcinoma
Location: Lake Success NY, New York NY, Philadelphia PA,
Sponsor: Gulam Manji

Sex: All

Age: 18+

Code: NCT06048484

Phase2, Recruiting

A Randomized Trial of Maintenance Systemic Therapy After Radiation for Oligometastatic Renal Cell Carcinoma (ASTROs)

for
Oligometastatic Renal Cell Carcinoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06004336

Phase2, Recruiting

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MethoTRExATE in MyelOpRolifErative Neoplasms (TREATMORE) Trial

for
Polycythemia Vera (PV), Essential Thrombocythemia (ET),
Location: New York NY
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All

Age: 18+

Code: NCT06541249

Phase2, Recruiting

A Trial to Learn How Well Linvoseltamab Works Compared to the Combination of Elotuzumab, Pomalidomide and Dexamethasone for Adult Participants With Relapsed/Refractory Multiple Myeloma

for
Relapsed Refractory Multiple Myeloma (RRMM)
Location: Durham NC
Sponsor: Regeneron Pharmaceuticals

Sex: All

Age: 18+

Code: NCT05730036

Phase3, Recruiting

Alemtuzumab and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II, Stage III, or Stage IV T-Cell Non-Hodgkin's Lymphoma

for
Lymphoma
Location: Toronto, Hamilton, London, Vancouver
Sponsor: Toronto Sunnybrook Regional Cancer Centre

Sex: All

Age: 18+

Code: NCT00363090

Phase1, Phase2, Recruiting

Practice Facilitation as a Strategy to Improve Alcohol Treatment Adoption and Implementation in HIV Care

for
Hiv, Alcohol Use, Unspecified
Location: San Diego CA
Sponsor: Johns Hopkins University

Sex: All

Age: 18+

Code: NCT05241990

Recruiting

Exploring the Benefit of Peripheral Nerve Stimulation in Treating Pain From Chemo-induced Peripheral Neuropathy: A Longitudinal Single Center Feasibility Study

for
Peripheral Nerve Stimulation,
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18 - 70+

Code: NCT06162403

Recruiting

Atezolizumab and Cabozantinib for the Treatment of Adolescents and Young Adults With Recurrent or Metastatic Osteosarcoma, TACOS Study

for
Locally Advanced Osteosarcoma, Metastatic Osteosarcoma,
Location: Boston MA, Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 12+

Code: NCT05019703

Phase2, Recruiting

Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

for
Low-grade Glioma
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT03948490

Recruiting

Psychoeducational Intervention for Patients With Hepatocellular Carcinoma

for
Hepatocellular Carcinoma
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: All

Age: 18+

Code: NCT06541990

Recruiting

Study Assessing the Effects of Early Psychiatric Referral on Mental Health and Quality of Life in People With Sarcoma

for
Sarcoma, Bone Sarcoma, Soft Tissue Sarcoma
Location: Commack NY, Uniondale NY, Harrison NY, New York NY,
Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All

Age: 18+

Code: NCT06129903

Recruiting

Detection of Oral and Throat Cancers Using OralViome Cancer Testing System

for
Oral Squamous Cell Carcinoma,
Location: New York NY
Sponsor: Viome

Sex: All

Age: 18+

Code: NCT05451303

Recruiting

Sleep Apnea in Patients With MGUS and MM

for
Multiple Myeloma,
Location: Iowa City IA
Sponsor: Michael Tomasson

Sex: All

Age: 18 - 70+

Code: NCT04114084

Recruiting

A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab

for
Melanoma
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT02621021

Phase2, Recruiting

Understanding and Preventing Cortical Mechanisms of Chemotherapy-induced Peripheral Neuropathy

for
Chemotherapy-induced Peripheral Neuropathy
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT06389721

Recruiting

1MoreStep: An Intervention to Increase HIV Care Engagement and Reduce Intimate Partner Violence Among Black Women Living With HIV

for
Violence, Domestic, HIV, Stigma, Social, Engagement, Patient,
Location: Baltimore MD
Sponsor: Johns Hopkins University

Sex: Female

Age: 18+

Code: NCT05608421

Recruiting

CAR T Cells Targeting CD30 Positive Lymphomas (4SCAR30273)

for
Lymphomas
Location: Gainesville FL
Sponsor: Peking University

Sex: All

Age: 18+

Code: NCT02274584

Phase1, Phase2, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer