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Oncology Clinical Trials

Browse 8,120 oncology clinical trials enrolling across the United States and Canada. 218 people applied to oncology studies last month. Search by city or state to find one near you.

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The Predictive Value of Coexisting TMPRSS2-ERG Gene Fusion and PTEN Deletion in Prostate Cancer Patients with Biochemical Failure Status Post Salvage or Radical Radiation Therapy

for
Prostate Cancer
Location: Quebec, Chicoutimi, Trois-Rivieres, Greenfield Park,
Sponsor: Sir Mortimer B. Davis - Jewish General Hospital

Sex: Male

Age: 18+

Code: NCT02573636

Recruiting

An Adjuvant Study to Evaluate SMS001 (Paclitaxel) in Non-Small Cell Lung Cancer

for
Carcinoma, Non-Small-Cell Lung Cancer (NSCLC)
Location: Toronto, Rochester MN
Sponsor: ToLymph Inc.

Sex: All

Age: 18 - 70+

Code: NCT06693336

Phase 2, Recruiting

PSMA-based 18F-DCFPyL PET/CT: Evaluating Its Application in Real Life

for
Prostate Cancer
Location: Kitchener
Sponsor: Grand River Hospital

Sex: Male

Age: 18+

Code: NCT03609736

Recruiting

A Phase 2 Single-Arm Open-Label Pilot Trial Evaluating Zanidatamab (ZW25) in Patients With Early Stage HER2/Neu Positive (HER2+) Breast Cancer (BC)

for
Breast Cancer, HER2-positive
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: Female

Age: 18+

Code: NCT05035836

Phase 2, Recruiting

A Pilot Phase II Study of Maintenance Cabozantinib Plus Pembrolizumab for Patients With Metastatic Squamous Non-Small Cell Lung Cancer (sqNSCLC)

for
Metastatic Squamous Non-Small Cell Lung Carcinoma
Location: Chicago IL
Sponsor: University of Illinois at Chicago

Sex: All

Age: 18+

Code: NCT05613413

Phase 2, Recruiting

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GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas (DIPG) & Spinal Diffuse Midline Glioma(DMG)

for
Glioma of Spinal Cord, Glioma of Brainstem
Location: Stanford CA
Sponsor: Stanford University

Sex: All

Age: 2 - 60

Code: NCT04196413

Phase 1, Recruiting

A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

for
Metastatic Uveal Melanoma
Location: Boston MA, New York NY, Philadelphia PA,
Sponsor: Replimune Inc.

Sex: All

Age: 0+

Code: NCT06581406

Phase 2, Phase 3, Recruiting

Study of KTE-X19 in Minimal Residual Disease (MRD) Positive B-Cell Acute Lymphoblastic Leukemia (B-ALL)

for
B-Cell Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT06144606

Phase 2, Recruiting

BettER: Biomarker Driven Early Therapeutic Selection in Patients With HR+ HER2- Metastatic or Unresectable Breast Cancer

for
Metastatic Breast Cancer, Unresectable Breast Cancer
Location: St Louis MO
Sponsor: Washington University School of Medicine

Sex: All

Age: 18+

Code: NCT05977036

Recruiting

Endoscopic Ultrasound Radiofrequency Ablation and Immunotherapy Pembrolizumab for Locally Advanced Unresectable and Metastatic Pancreatic Duct Adenocarcinoma

for
Pancreatic Ductal Adenocarcinoma
Location: Houston TX
Sponsor: The University of Texas Health Science Center, Houston

Sex: All

Age: 18+

Code: NCT06831136

Phase 2, Recruiting

Reduced CT + Anti-PD-1 as First Line Tx in Vulnerable Older Adults w/Adv <50% PD-L1 Non-Small Cell Lung Cancer (NSCLC)

for
Non-Small Cell Lung Cancer, NSCLC,
Location: Tappahannock VA, Richmond VA
Sponsor: Virginia Commonwealth University

Sex: All

Age: 18+

Code: NCT06731413

Phase 2, Recruiting

International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository

for
Diffuse Intrinsic Pontine Glioma,
Location: Cincinnati OH
Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All

Age: 0+

Code: NCT03101813

Recruiting

Evaluation of Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography in Patients With Sarcoma

for
Bone Sarcoma, Soft Tissue Sarcoma
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06409013

Recruiting

PT-112 in Subjects With Thymoma and Thymic Carcinoma

for
Thymic Epithelial Tumor, Recurrent Thymoma, Thymic Cancer
Location: Bethesda MD
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18 - 70+

Code: NCT05104736

Phase 2, Recruiting

Optimized Cord Blood Transplantation for the Treatment of Patients With High-risk Hematologic Malignancies Who Have Relapsed After First Allogeneic Stem Cell Transplantation

for
Hematologic Malignancies
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 0 - 60

Code: NCT06807606

Phase 2, Recruiting

Phase 2 Randomized Trial of Flexible Dosing Schedule of 177Lu-PSMA-617 for the Treatment of Metastatic Castration-Resistant Prostate Cancer (FLEX-MRT)

for
Prostate Carcinoma,
Location: Los Angeles CA
Sponsor: Jonsson Comprehensive Cancer Center

Sex: Male

Age: 18+

Code: NCT06216249

Phase 2, Recruiting

Mitoxantrone for Venetoclax Resistant Acute Myeloid Leukemia

for
Leukemia, Myeloid Leukemia, Monocytic Leukemia
Location: Aurora CO
Sponsor: University of Colorado, Denver

Sex: All

Age: 18 - 70+

Code: NCT06429449

Phase 1, Recruiting

Proton Radiation for Unresectable, Borderline Resectable, or Medically Inoperable Carcinoma of the Pancreas

for
Pancreatic Cancer
Location: Flint MI, Warrenville IL, Little Rock AR
Sponsor: Proton Collaborative Group

Sex: All

Age: 18+

Code: NCT02598349

Phase 2, Recruiting

Quality of Life, Lifestyle, and Psychosocial Factors in Patients With Melanoma

for
Cutaneous Melanoma
Location: Houston TX
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04778449

Recruiting

Non-endoscopic Esophageal Sampling to Detect Barrett's Esophagus and Esophageal Cancer in Veterans

for
Barrett Esophagus, GERD, Obesity, Esophageal Cancer
Location: Cleveland OH
Sponsor: Cleveland VA Medical Research and Education Foundation

Sex: All

Age: 40 - 70+

Code: NCT05210049

Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer