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Oncology Clinical Trials

Browse 8,863 oncology clinical trials enrolling across the United States and Canada. Search by city or state to find one near you.

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Duration of Anti-PD-1 Therapy in Metastatic Melanoma

for
Unresectable/Metastatic Melanoma
Location: Fredericton, Montreal, Ottawa, Kingston, Oshawa,
Sponsor: Canadian Cancer Trials Group

Sex: All

Age: 18+

Code: NCT02821013

Phase3, Recruiting

Circulating Tumor Cell Analysis in Patients With Localized Prostate Cancer Undergoing Prostatectomy

for
Prostate Cancer
Location: Boston MA
Sponsor: Massachusetts General Hospital

Sex: Male

Age: 18+

Code: NCT01961713

Recruiting

Combining Sunitinib, Temozolomide and Radiation to Treat Patients Diagnosed With Glioblastoma

for
Glioblastoma Multiforme
Location: Montreal, Calgary
Sponsor: Bassam Abdulkarim

Sex: All

Age: 18 - 70

Code: NCT02928575

Phase2, Recruiting

Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis

for
Recurrent Acute Pancreatitis, Chronic Pancreatitis
Location: Pittsburgh PA, Columbus OH, Los Angeles CA, Stanford CA
Sponsor: Cedars-Sinai Medical Center

Sex: All

Age: 18 - 70+

Code: NCT05771675

Early_phase1, Recruiting

Relugolix and Enzalutamide in Combination With Radiation Therapy for the Treatment of Very High Risk Prostate Cancer, OPTIMAL Trial

for
Prostate Adenocarcinoma
Location: Chicago IL
Sponsor: Sean Sachdev

Sex: Male

Age: 18+

Code: NCT06499870

Phase2, Recruiting

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Keeping it LITE: Exploring HIV Risk in Vulnerable Youth With Limited Interaction and Digital Health Intervention

for
HIV Infections, Sexual Behavior
Location: Chicago IL
Sponsor: Hektoen Institute for Medical Research

Sex: All

Age: 13 - 34

Code: NCT05848570

Recruiting

Preoperative 5-Day Radiotherapy for Soft Tissue Sarcoma

for
Soft Tissue Sarcoma
Location: Charleston SC
Sponsor: Medical University of South Carolina

Sex: All

Age: 18+

Code: NCT06905132

Phase2, Recruiting

A Pilot Phase II Study of Maintenance Cabozantinib Plus Pembrolizumab for Patients With Metastatic Squamous Non-Small Cell Lung Cancer (sqNSCLC)

for
Metastatic Squamous Non-Small Cell Lung Carcinoma
Location: Chicago IL
Sponsor: University of Illinois at Chicago

Sex: All

Age: 18+

Code: NCT05613413

Phase2, Recruiting

A Study Evaluating An Integrated Pharmacy Digital Diary and Delivery Strategy to Increase PrEP Use Among MSM and TGW

for
HIV Prevention, Pre-exposure Prophylaxis (PrEP), Risk Reduction,
Location: San Francisco CA
Sponsor: Public Health Foundation Enterprises, Inc.

Sex: Male

Age: 18+

Code: NCT05474313

Recruiting

Natural History of Medullary Thyroid Cancer to Inform Advanced Disease Management

for
Advanced Thyroid Gland Medullary Carcinoma,
Location: Houston TX, San Francisco CA
Sponsor: M.D. Anderson Cancer Center

Sex: All

Age: 18+

Code: NCT04216732

Recruiting

A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

for
Metastatic Uveal Melanoma
Location: Boston MA, New York NY, Philadelphia PA,
Sponsor: Replimune Inc.

Sex: All

Age: 0+

Code: NCT06581406

Phase2, Phase3, Recruiting

Study of KTE-X19 in Minimal Residual Disease (MRD) Positive B-Cell Acute Lymphoblastic Leukemia (B-ALL)

for
B-Cell Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia
Location: Tampa FL
Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All

Age: 18+

Code: NCT06144606

Phase2, Recruiting

A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS)

for
Myelodysplastic Syndromes, Cytopenia
Location: Shirley NY, Hackensack NJ, Bethesda MD, Miami FL,
Sponsor: Takeda

Sex: All

Age: 18+

Code: NCT04419649

Phase2, Recruiting

PET Imaging Study of 64Cu-GRIP B for Patients Receiving CD19-directed CAR-T Therapy

for
Non Hodgkin Lymphoma
Location: San Francisco CA
Sponsor: Michael Randall

Sex: All

Age: 18+

Code: NCT06522932

Phase1, Recruiting

Endoscopic Ultrasound Radiofrequency Ablation and Immunotherapy Pembrolizumab for Locally Advanced Unresectable and Metastatic Pancreatic Duct Adenocarcinoma

for
Pancreatic Ductal Adenocarcinoma
Location: Houston TX
Sponsor: The University of Texas Health Science Center, Houston

Sex: All

Age: 18+

Code: NCT06831136

Phase2, Recruiting

Molecular Residual Disease Interception in Locoregionally-Advanced High Risk HPV+ and HPV- HNSCC

for
Locoregionally Advanced Head and Neck Squamous Cell Carcinoma (LA-HNSCC),
Location: Toronto
Sponsor: University Health Network, Toronto

Sex: All

Age: 18+

Code: NCT05414032

Phase2, Recruiting

International Diffuse Intrinsic Pontine Glioma (DIPG)/Diffuse Midline Glioma (DMG) Registry and Repository

for
Diffuse Intrinsic Pontine Glioma,
Location: Cincinnati OH
Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All

Age: 0+

Code: NCT03101813

Recruiting

CONNECTing to LungCare

for
Smoking Cessation, Cigarette Smoking-Related Carcinoma,
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT06213532

Recruiting

Evaluation of Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography in Patients With Sarcoma

for
Bone Sarcoma, Soft Tissue Sarcoma
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: All

Age: 18+

Code: NCT06409013

Recruiting

KRT-232 in Combination With TL-895 for the Treatment of R/R MF and KRT-232 for the Treatment of JAKi Intolerant MF

for
Myelofibrosis, Post-PV MF, Post-ET Myelofibrosis,
Location: New York NY, Fort Lee NJ, Lake City FL, Birmingham AL,
Sponsor: Kartos Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT04640532

Phase1, Phase2, Recruiting

What is oncology?

Oncology is the branch of medicine focused on cancer. Cancer itself is not a single disease. It is a family of more than 100 diseases, from breast cancer and lung cancer to blood cancers like leukemia and lymphoma. What they share is the same basic problem: cells that grow and divide without stopping. About 4 in 10 people in the US will be diagnosed with some form of cancer during their lifetime.

Cancer research moves faster than almost any other field of medicine. Cancer drugs made up about 35% of all new FDA drug approvals in 2025, 16 new medicines in one year. The 5 year survival rate for all cancers combined reached 70% for people diagnosed in 2015 to 2021, a first in US history. And survival for metastatic (spread) cancer has doubled since the mid 1990s, from 17% to 35%. Every one of those gains came through clinical trials.

Who can participate in oncology trials?

Do oncology trial participants get paid?

Types of cancer clinical trials

The stages of cancer, and why they matter for trials

How to enroll in a clinical trial for cancer