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Opioid Use Disorder Clinical Trials

Browse 196 Opioid Use Disorder clinical trials enrolling across the United States and Canada. 87 people applied to Opioid Use Disorder studies last month. Search by city or state to find one near you.

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High Dose Buprenorphine (BUP) Induction in the Emergency Department (ED)

for
Opioid Use Disorder
Location: Newark NJ
Sponsor: Rutgers, The State University of New Jersey

Sex: All

Age: 18+

Code: NCT05589181

Phase3, Recruiting

Brain Training for Substance Use Disorders

for
Opioid Use Disorder
Location: Minneapolis MN
Sponsor: Neurotype Inc.

Sex: All

Age: 18 - 65

Code: NCT06870110

Recruiting

Young Houston Emergency Opioid Engagement System

for
Opioid-use Disorder, Opioid Dependence, Opioid Overdose,
Location: Houston TX
Sponsor: The University of Texas Health Science Center, Houston

Sex: All

Age: 13 - 17

Code: NCT04811014

Recruiting

Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial

for
Opioid Use Disorder, Opioid Misuse, Chronic Pain
Location: Arcata CA
Sponsor: University of New Mexico

Sex: All

Age: 18+

Code: NCT06565416

Recruiting

Evaluating Tetrahydrocannabinol as an Adjunct to Opioid Agonist Therapy

for
Opioid Use Disorder, Methadone, Cannabis, Fentanyl
Location: Vancouver
Sponsor: BC Centre on Substance Use

Sex: All

Age: 25+

Code: NCT05985850

Phase2, Recruiting

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The Youth Opioid Recovery Support (YORS) Intervention

for
Opioid-use Disorder, Medication Adherence
Location: Baltimore MD
Sponsor: Potomac Health Foundations

Sex: All

Age: 18 - 28

Code: NCT04173416

Recruiting

Collaborative Opioid Taper After Trauma: Preventing Opioid Misuse and Opioid Use Disorder

for
Opioid Use, Pain, Postoperative, Opioid Use, Unspecified,
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 18+

Code: NCT04275258

Recruiting

Evaluating the Pharmacokinetics and Patient Outcomes of Buprenorphine Microdosing

for
Opioid Use Disorder, Opioid Withdrawal
Location: Binghamton NY
Sponsor: United Health Services Hospitals, Inc.

Sex: All

Age: 18+

Code: NCT05307458

Recruiting

Adjunctive Effects of Psilocybin and a Formulation of Buprenorphine

for
Opioid Use Disorder
Location: Madison WI
Sponsor: University of Wisconsin, Madison

Sex: All

Age: 21 - 65

Code: NCT04161066

Phase1, Recruiting

Extended-release Injectable Buprenorphine for Individuals at High Risk of Overdose

for
Opioid-Use Disorder, Opioid Overdose
Location: Vancouver
Sponsor: BC Centre on Substance Use

Sex: All

Age: 19+

Code: NCT04815590

Recruiting

GLP-1R Agonist Treatment for Opioid Use Disorder

for
Opioid Use Disorder, Opioid Abuse and Addiction,
Location: Fall River MA, New York NY, Harrisburg PA
Sponsor: Milton S. Hershey Medical Center

Sex: All

Age: 18 - 70+

Code: NCT06548490

Phase2, Recruiting

Evaluation of a Peer Recovery Support Program Adapted to Target Retention in Clinic-based Medication for Opioid Use Disorder Treatment

for
Opioid Use Disorder
Location: Danville PA
Sponsor: Geisinger Clinic

Sex: All

Age: 18 - 70+

Code: NCT07197801

Recruiting

Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning

for
Schizophrenia, Cannabis Dependence,
Location: New Haven CT
Sponsor: Yale University

Sex: Male

Age: 18 - 55

Code: NCT01730781

Recruiting

Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data

for
Opioid Use Disorder, Opioid Use
Location: Seattle WA
Sponsor: University of Washington

Sex: All

Age: 18+

Code: NCT06768814

Recruiting

Supporting Treatment Access and Recovery in COD

for
Opioid Use Disorder, Mental Health Disorder
Location: Worcester MA, Orange MA, Springfield MA, Holyoke MA
Sponsor: University of Massachusetts, Worcester

Sex: All

Age: 18+

Code: NCT05138614

Recruiting

Opioid Treatment and Peer Recovery Support

for
Opioid-use Disorder
Location: Providence RI, Philadelphia PA, Durham NC
Sponsor: Brown University

Sex: All

Age: 18+

Code: NCT04978168

Recruiting

Project I Test: Implementing HIV Testing in Opioid Treatment Programs

for
HIV/AIDS, Hepatitis C, Substance Use Disorders,
Location: New York NY
Sponsor: Columbia University

Sex: All

Age: 18+

Code: NCT03135886

Recruiting

Injectable Extended-Release Buprenorphine (XR-B) in a Correctional Setting: Qualitative Interviews

for
Opioid Use Disorder, Criminal Justice,
Location: Cranston RI
Sponsor: Lifespan

Sex: All

Age: 18+

Code: NCT06354465

Recruiting

EXPANDED SCOPE for Parent Grant Entitled, "Peer Recovery Support Services for Individuals in Recovery Residences on MOUD"

for
Opioid Use Disorder
Location: Baltimore MD
Sponsor: Potomac Health Foundations

Sex: All

Age: 18+

Code: NCT06696157

Recruiting

Using Facebook to Support Opioid Recovery Among American Indian Women

for
Opioid Use Disorder
Location: Rochester MN
Sponsor: Mayo Clinic

Sex: Female

Age: 18+

Code: NCT05995886

Recruiting

What are Opioid Use Disorder clinical trials?

Opioid use disorder is now understood much like other chronic health conditions: ongoing management and support tend to work far better than a single fixed intervention, similar to how diabetes or high blood pressure are managed over time rather than resolved once. Opioid Use Disorder clinical trials are research studies that explore different approaches to supporting recovery, reducing overdose risk, and helping people manage cravings and withdrawal. Researchers use these studies to better understand what actually helps people build long-term recovery, and how different types of support, including counseling and medications for opioid use disorder, affect outcomes over time.

The importance of clinical trials in Opioid Use Disorder research

Opioid clinical trials are an important part of how opioid use disorder is understood and addressed at a national level. They help researchers learn more about recovery patterns, identify what kind of support works best for different people, and offer structured, closely monitored pathways for those seeking help. This kind of research also helps shape recovery programs and public health efforts nationwide.

Types of Opioid Use Disorder clinical trials

Who can participate in Opioid Use Disorder clinical trials?

Does information stay confidential when participating in an Opioid Use Disorder clinical trial?

How to enroll in a clinical trial for Opioid Use Disorder