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Opioid Use Disorder Clinical Trials

Browse 196 Opioid Use Disorder clinical trials enrolling across the United States and Canada. 87 people applied to Opioid Use Disorder studies last month. Search by city or state to find one near you.

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SMART Brain Health in African-Americans

for
Opioid Use Disorder, Substance Use Disorders,
Location: Washington DC
Sponsor: Howard University

Sex: All

Age: 18 - 70+

Code: NCT03861832

Recruiting

Computerized Chemosensory-Based Orbitofrontal Cortex (CBOT) for Opioid Use Disorder

for
Opioid Use Disorder, Moderate, Opioid Use Disorder, Severe,
Location: Washington DC, Rockville MD
Sponsor: Evon Medics LLC

Sex: All

Age: 18 - 70

Code: NCT04850664

Phase2, Recruiting

OMAR Opioid Use Disorder

for
Healthy Control, Opioid Use Disorder
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 18+

Code: NCT05683184

Phase1, Recruiting

Divided or Single Exposure (DOSE) Study

for
Opioid Use Disorder, Chronic Pain, Methadone
Location: Baltimore MD
Sponsor: University of Maryland, Baltimore

Sex: All

Age: 18 - 70+

Code: NCT05459402

Phase2, Phase3, Recruiting

Rapid Outpatient Low-dose Initiation of Buprenorphine for OUD With Fentanyl Use

for
Opioid Use Disorder
Location: Philadelphia PA
Sponsor: University of Pennsylvania

Sex: All

Age: 18+

Code: NCT06379984

Phase2, Recruiting

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Removing Barriers: Community Partnering for Innovative Solutions to the Opioid Crisis

for
Opioid Use Disorder, Alcohol Use Disorder,
Location: Ypsilanti MI, Ann Arbor MI
Sponsor: University of Michigan

Sex: All

Age: 18+

Code: NCT05665179

Recruiting

Trauma Screening/Referral and Interpersonal Violence Prevention for Women with Substance Use Disorders

for
Substance Use Disorders, Posttraumatic Stress Disorder,
Location: Greenville SC
Sponsor: Clemson University

Sex: Female

Age: 18+

Code: NCT06608979

Recruiting

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

for
Opioid-use Disorder, Substance Use Disorders
Location: New York NY, Baltimore MD, Morgantown WV
Sponsor: InSightec

Sex: All

Age: 18 - 60

Code: NCT04197921

Recruiting

PrEP and MOUD Rapid Access for Persons Who Inject Drugs: The CHORUS+ Study

for
Opioid Use Disorder
Location: Boston MA
Sponsor: Boston Medical Center

Sex: All

Age: 18+

Code: NCT05769218

Recruiting

LIFU for Treatment for Refractory Opioid Use Disorder

for
Opioid Use Disorder
Location: Morgantown WV
Sponsor: Ali Rezai

Sex: All

Age: 22 - 60

Code: NCT06218706

Recruiting

Intervening on Opioid Use and Loneliness

for
Opioid Use Disorder, Loneliness, Social Isolation
Location: Rochester NY
Sponsor: University of Rochester

Sex: All

Age: 18+

Code: NCT06458335

Recruiting

Predicting and Preventing Adverse Maternal and Child Outcomes of Opioid Use Disorder in Pregnancy

for
Opioid Use Disorder, Pregnancy Related
Location: Pittsburgh PA
Sponsor: Ilana Hull

Sex: Female

Age: 18+

Code: NCT05942313

Recruiting

Low-dose Buprenorphine Initiation for Opioid Use Disorder

for
Opioid Use Disorder
Location: The Bronx NY
Sponsor: Montefiore Medical Center

Sex: All

Age: 18+

Code: NCT05450718

Recruiting

Optimizing Evidence-based HIV Prevention Targeting People Who Inject Drugs on PrEP

for
Hiv, Opioid Use Disorder
Location: New Haven CT
Sponsor: University of Connecticut

Sex: All

Age: 18+

Code: NCT05669534

Recruiting

Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

for
Opioid Withdrawal, Opioid Use Disorder, Opioid Craving
Location: Baltimore MD
Sponsor: University of Maryland, Baltimore

Sex: All

Age: 18 - 65

Code: NCT05027919

Phase2, Recruiting

Interim Buprenorphine Treatment to Bridge Waitlist Delays: Stage II Evaluation

for
Opioid-use Disorder
Location: Burlington VT
Sponsor: University of Vermont

Sex: All

Age: 18+

Code: NCT03420313

Phase2, Recruiting

Teaching Health Resilience in a Hospital Setting: A Peer-led Intervention

for
Opioid Use Disorder, Harm Reduction, Health Promotion
Location: Pittsburgh PA
Sponsor: University of Pennsylvania

Sex: All

Age: 18+

Code: NCT06843213

Recruiting

Adaptive Decision Support for Addiction Treatment Master

for
Opioid Use Disorder
Location: Guilford CT, New Haven CT
Sponsor: Yale University

Sex: All

Age: 18+

Code: NCT06799117

Recruiting

Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders

for
Substance Use Disorders, Opioid Use Disorder,
Location: Washington DC
Sponsor: Evon Medics LLC

Sex: All

Age: 18 - 70+

Code: NCT06434818

Phase2, Recruiting

Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness

for
Opioid Use Disorder, Dual Diagnosis, Housing Problems,
Location: Columbus OH
Sponsor: Ohio State University

Sex: All

Age: 14 - 24

Code: NCT06311838

Recruiting

What are Opioid Use Disorder clinical trials?

Opioid use disorder is now understood much like other chronic health conditions: ongoing management and support tend to work far better than a single fixed intervention, similar to how diabetes or high blood pressure are managed over time rather than resolved once. Opioid Use Disorder clinical trials are research studies that explore different approaches to supporting recovery, reducing overdose risk, and helping people manage cravings and withdrawal. Researchers use these studies to better understand what actually helps people build long-term recovery, and how different types of support, including counseling and medications for opioid use disorder, affect outcomes over time.

The importance of clinical trials in Opioid Use Disorder research

Opioid clinical trials are an important part of how opioid use disorder is understood and addressed at a national level. They help researchers learn more about recovery patterns, identify what kind of support works best for different people, and offer structured, closely monitored pathways for those seeking help. This kind of research also helps shape recovery programs and public health efforts nationwide.

Types of Opioid Use Disorder clinical trials

Who can participate in Opioid Use Disorder clinical trials?

Does information stay confidential when participating in an Opioid Use Disorder clinical trial?

How to enroll in a clinical trial for Opioid Use Disorder