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Opioid Use Disorder Clinical Trials

Browse 196 Opioid Use Disorder clinical trials enrolling across the United States and Canada. 87 people applied to Opioid Use Disorder studies last month. Search by city or state to find one near you.

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Active & Responsive

Opioid Use Disorder in Pregnancy in Long-Term Maternal/Infant Outcomes

for
Opioid-use Disorder, Opioid Use, Unspecified,
Location: Pittsburgh PA
Sponsor: Senthil Sadhasivam

Sex: Female

Age: 18+

Code: NCT03923374

Recruiting
Active & Responsive

Project STRONGER: Stepped Care for Opioid Use Disorder Treatment Engagement and Recovery

for
Opioid Use Disorder, Intimate Partner Violence (IPV),
Location: West Haven CT, Bridgeport CT
Sponsor: Yale University

Sex: Female

Age: 18+

Code: NCT07115030

Recruiting
Active & Responsive

Sustaining Recovery for People on Opioid Agonist Treatment With Conversational Agents

for
Opioid Use Disorder
Location: Boston MA
Sponsor: Boston Medical Center

Sex: All

Age: 18+

Code: NCT06732596

Recruiting
Active & Responsive

Adjunctive Cannabidiol for Recovery From Opioid Study

for
Opioid Use Disorder (OUD)
Location: New York NY, Portland OR
Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All

Age: 18 - 65

Code: NCT06940674

Phase3, Recruiting
Active & Responsive

Non-invasive Vagal Nerve Stimulation in Opioid Use Disorders UH3

for
Withdrawal Symptoms, Opioid Use Disorder, Opioid Use
Location: Atlanta GA
Sponsor: Emory University

Sex: All

Age: 18 - 70+

Code: NCT05834478

Phase3, Recruiting

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Active & Responsive

E-Cigarettes for Harm Reduction in Smokers With Opioid Use Disorder

for
Opioid Use Disorder, Cigarette Smoking
Location: New York NY
Sponsor: NYU Langone Health

Sex: All

Age: 21 - 70+

Code: NCT05722561

Phase2, Recruiting
Active & Responsive

Using Clinical Decision Support to Provide Social Risk-Informed Care for Opioid Use Disorder in the Emergency Department

for
Opioid Use Disorder, Social Determinants of Health (SDOH)
Location: San Francisco CA
Sponsor: University of California, San Francisco

Sex: All

Age: 18+

Code: NCT06872190

Recruiting
Active & Responsive

Mirtazapine for the Treatment of Methamphetamine Use in Opioid Use Disorder Patients Receiving Medication Assisted Treatment

for
Stimulant Use Disorder
Location: Spokane WA
Sponsor: Washington State University

Sex: All

Age: 18+

Code: NCT06323837

Phase2, Recruiting
Active & Responsive

A Study of Suvorexant (MK-4305) for the Treatment of Insomnia Disorder in Participants With Opioid Use Disorder (MK-4305-098)

for
Insomnia
Location: Providence RI, New Haven CT, Marlton NJ,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18 - 70

Code: NCT06655883

Phase3, Recruiting
Active & Responsive

Long-Term Treatment of Opioid Use Disorder

for
Drug Addiction, Employment
Location: Marquette MI
Sponsor: Northern Michigan University

Sex: All

Age: 18+

Code: NCT05534815

Recruiting
Active & Responsive

The MOUD Plus Pilot: Counseling and Peer Support to Support Retention for Medically Complex Patients With Opioid Use Disorder Seen In Primary Care

for
Opioid Dependence, Substance Abuse Disorders,
Location: Portland OR
Sponsor: Oregon Health and Science University

Sex: All

Age: 18+

Code: NCT06837662

Recruiting
Active & Responsive

Leveraging Regulatory Flexibility for Methadone Take-Home Dosing to Improve Retention in Treatment for Opioid Use Disorder

for
Problems Related to Social Environment
Location: Storrs CT, New York NY, Buffalo NY
Sponsor: NYU Langone Health

Sex: All

Age: 18+

Code: NCT05675735

Recruiting
Active & Responsive

Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

for
Knee Injuries, Pain, Postoperative, Opioid Use
Location: Fargo ND
Sponsor: Sanford Health

Sex: All

Age: 18 - 70+

Code: NCT03858231

Recruiting
New

Characterization of CB1 Receptors Using [11-C]OMAR in Opioid Use Disorder

for
Opioid Use Disorder, OAT
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 25 - 65

Code: NCT07800520

Phase1, Recruiting
New

A Bundled Intervention to End Opioid Overdoses

for
Opioid Use Disorder, Opioid Overdose
Location: Birmingham AL
Sponsor: University of Alabama at Birmingham

Sex: All

Age: 19+

Code: NCT07485335

Recruiting
New

A Clinical Trial of Telehealth Treatment for Opioid Use Disorders

for
Opioid Use Disorder
Location: New Haven CT
Sponsor: Yale University

Sex: All

Age: 18+

Code: NCT07362082

Recruiting
New

Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder

for
Medication Abuse, Harm Reduction, Opioid Use Disorder,
Location: Aurora CO
Sponsor: University of Colorado, Denver

Sex: All

Age: 12 - 70+

Code: NCT06526286

Recruiting

Continuum of Care in Hospitalized Patients With Opioid/Stimulant Use Disorder and Infectious Complications From Drug Use

for
Opioid Use Disorder, Injection Related Infections,
Location: Baltimore MD, Washington D.C. DC, Morgantown WV,
Sponsor: Elana Rosenthal

Sex: All

Age: 18+

Code: NCT06513156

Recruiting

Integrated Treatment for Opioid Use Disorder and PTSD

for
Opioid Use Disorder, Posttraumatic Stress Disorder (PTSD)
Location: Charleston SC
Sponsor: Medical University of South Carolina

Sex: All

Age: 18 - 70

Code: NCT06641115

Recruiting

Disclosure Intervention for People in Treatment for Opioid Use Disorder

for
Opioid Use Disorder
Location: Wilmington DE
Sponsor: University of Delaware

Sex: All

Age: 18+

Code: NCT06458985

Recruiting

What are Opioid Use Disorder clinical trials?

Opioid use disorder is now understood much like other chronic health conditions: ongoing management and support tend to work far better than a single fixed intervention, similar to how diabetes or high blood pressure are managed over time rather than resolved once. Opioid Use Disorder clinical trials are research studies that explore different approaches to supporting recovery, reducing overdose risk, and helping people manage cravings and withdrawal. Researchers use these studies to better understand what actually helps people build long-term recovery, and how different types of support, including counseling and medications for opioid use disorder, affect outcomes over time.

The importance of clinical trials in Opioid Use Disorder research

Opioid clinical trials are an important part of how opioid use disorder is understood and addressed at a national level. They help researchers learn more about recovery patterns, identify what kind of support works best for different people, and offer structured, closely monitored pathways for those seeking help. This kind of research also helps shape recovery programs and public health efforts nationwide.

Types of Opioid Use Disorder clinical trials

Who can participate in Opioid Use Disorder clinical trials?

Does information stay confidential when participating in an Opioid Use Disorder clinical trial?

How to enroll in a clinical trial for Opioid Use Disorder