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Paid Clinical Trials Knoxville

Discover 213 paid clinical trials in Knoxville, Tennessee. Search by condition or phase to find a research study near you that matches your needs across various therapeutic areas.

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Active & Responsive

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema

for
Emphysema, Pulmonary, Emphysema or COPD
Location: Knoxville TN, Pittsburgh PA, Falls Church VA,
Sponsor: Pulmonx Corporation

Sex: All

Age: 40 - 70+

Code: NCT06035120

Recruiting
Active & ResponsiveNew

Studying NMDA and Sigma-1 in Smoking Cessation Treatment (SUMMIT)

for
Smoking Cessation
Location: Knoxville TN, Stockbridge GA, Evansville IN, Memphis TN,
Sponsor: Axsome Therapeutics, Inc.

Sex: All

Age: 18 - 65

Code: NCT07766655

Phase3, Recruiting
Active & Responsive

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

for
Heart Failure With Preserved Ejection Fraction,
Location: Powell TN, Oak Ridge TN, Lexington KY, Tullahoma TN,
Sponsor: Amgen

Sex: All

Age: 18 - 70+

Code: NCT07037459

Phase3, Recruiting
Active & Responsive

Daily Eating Patterns for Total Health Study

for
Obesity
Location: Knoxville TN
Sponsor: The University of Tennessee, Knoxville

Sex: All

Age: 25 - 60

Code: NCT06455995

Recruiting
Active & Responsive

Early Childhood Dietary Assessment Study

for
Dietary Assessment
Location: Knoxville TN
Sponsor: The University of Tennessee, Knoxville

Sex: All

Age: 2 - 5

Code: NCT07227272

Recruiting

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Active & Responsive

ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

for
Autosomal Dominant Polycystic Kidney Disease
Location: Knoxville TN, Chattanooga TN, Atlanta GA,
Sponsor: Calico Life Sciences LLC

Sex: All

Age: 18 - 55

Code: NCT06902558

Phase2, Recruiting
Active & Responsive

A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)

for
Macular Degeneration, Age-Related Macular Degeneration,
Location: Knoxville TN, Asheville NC, Johnson City TN, Hixson TN,
Sponsor: EyeBiotech Ltd.

Sex: All

Age: 50+

Code: NCT07496567

Phase2, Phase3, Recruiting
Active & Responsive

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

for
PIK3CA Mutation, HER2- Negative Breast Cancer,
Location: Knoxville TN, Atlanta GA, Nashville TN, Indianapolis IN,
Sponsor: Relay Therapeutics, Inc.

Sex: All

Age: 18+

Code: NCT06982521

Phase3, Recruiting
Active & Responsive

OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events

for
Cardiovascular Disease
Location: Oak Ridge TN, Chattanooga TN, Cumming GA, Gantt SC,
Sponsor: Amgen

Sex: All

Age: 50 - 70+

Code: NCT07136012

Phase3, Recruiting

Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

for
Anatomic Stage II Breast Cancer AJCC v8,
Location: Corbin KY, Johns Creek GA, Lexington KY, Decatur GA,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06058377

Phase3, Recruiting

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

for
Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma,
Location: Knoxville TN, Lexington KY, Atlanta GA, Nashville TN,
Sponsor: Sameek Roychowdhury

Sex: All

Age: 18+

Code: NCT06906562

Phase2, Recruiting

Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial)

for
Myelodysplastic Syndrome
Location: Knoxville TN, Seneca SC, Easley SC, Greenville SC,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06577441

Phase2, Recruiting

IMC-F106C Regimen Versus Nivolumab Regimens in Previously Untreated Advanced Melanoma (PRISM-MEL-301)

for
Advanced Melanoma
Location: Knoxville TN, Greenville SC, Spartanburg SC,
Sponsor: Immunocore Ltd

Sex: All

Age: 18+

Code: NCT06112314

Phase3, Recruiting

VO and Nivolumab vs Physician's Choice in Advanced Melanoma That Progressed on Anti-PD-1 & Anti-CTLA-4 Drugs [IGNYTE-3]

for
Advanced Melanoma
Location: Knoxville TN, Atlanta GA, Louisville KY, Chapel Hill NC,
Sponsor: Replimune, Inc.

Sex: All

Age: 12+

Code: NCT06264180

Phase3, Recruiting

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

for
Carcinoma, Non-Small-Cell Lung
Location: Knoxville TN, Chattanooga TN, Atlanta GA, Nashville TN,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT06667076

Phase2, Recruiting

DAREON®-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer (epNEC) to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy

for
Extrapulmonary Neuroendocrine Cancer (epNEC)
Location: Knoxville TN, Atlanta GA, St Louis MO, Duarte CA
Sponsor: Boehringer Ingelheim

Sex: All

Age: 18+

Code: NCT07544654

Phase3, Recruiting

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

for
Acute Myeloid Leukemia
Location: Knoxville TN, Seneca SC, Easley SC, Greenville SC,
Sponsor: National Cancer Institute (NCI)

Sex: All

Age: 18+

Code: NCT06672146

Phase2, Recruiting

Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers

for
Pancreatic Neoplasm
Location: Knoxville TN, Greenville SC, Atlanta GA, Nashville TN,
Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All

Age: 50 - 70+

Code: NCT04239573

Recruiting

E-Mindfulness Approaches for Living After Breast Cancer

for
Breast Cancer, Depression
Location: Knoxville TN, Seneca SC, Easley SC, Greenville SC,
Sponsor: NRG Oncology

Sex: All

Age: 18 - 50

Code: NCT06748222

Phase3, Recruiting

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

for
Leukemia, Myeloid, Acute
Location: Knoxville TN, Lexington KY, Nashville TN, Charlotte NC,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 18+

Code: NCT06852222

Phase3, Recruiting