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Paid Clinical Trials Knoxville

Discover 213 paid clinical trials in Knoxville, Tennessee. Search by condition or phase to find a research study near you that matches your needs across various therapeutic areas.

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Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

for
Pancreatic Neuroendocrine Tumor (pNET),
Location: Knoxville TN, Lexington KY, Nashville TN, Birmingham AL,
Sponsor: Exelixis

Sex: All

Age: 18+

Code: NCT06943755

Phase 2, Phase 3, Recruiting

A Clinical Study of Gocatamig (MK-6070) and Infinatamab Deruxtecan (MK-2400) in People With Small Cell Lung Cancer (MK-6070-003)

for
Small Cell Lung Cancer Extensive Stage
Location: Knoxville TN, Nashville TN, Edgewood KY,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT07227597

Phase 1, Phase 2, Recruiting

Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC

for
Hepatocellular Carcinoma, Biliary Tract Cancer
Location: Knoxville TN, Germantown TN, Pittsburgh PA,
Sponsor: Replimune Inc.

Sex: All

Age: 18+

Code: NCT05733598

Phase 2, Recruiting

Use of Impedance Cardiography to Decrease the Risk of Pre-eclampsia in Obese Patients

for
Obesity, Morbid, Preeclampsia
Location: Knoxville TN
Sponsor: University of Tennessee Graduate School of Medicine

Sex: Female

Age: 18 - 51

Code: NCT03105661

Early Phase 1, Recruiting

Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia

for
Preeclampsia, Preeclampsia (PE), Preeclampsia (PE) Risk,
Location: Knoxville TN
Sponsor: University of Tennessee Graduate School of Medicine

Sex: Female

Age: 18 - 45

Code: NCT06802861

Recruiting

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A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

for
Diffuse Large B-Cell Lymphoma
Location: Knoxville TN, Greenville SC, Athens GA, Lexington KY,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06717347

Phase 3, Recruiting

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

for
Carcinoma, Non-Small-Cell Lung
Location: Knoxville TN, Chattanooga TN, Athens GA, Lexington KY,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06890598

Phase 3, Recruiting

Y90 Radioembolization Dose Delivery and Radiation Exposure Assessment

for
Hepatocellular Carcinoma, Radiation Exposure
Location: Knoxville TN
Sponsor: University of Tennessee

Sex: All

Age: 18+

Code: NCT03686709

Recruiting

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

for
Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
Location: Knoxville TN, Chattanooga TN, Greenville SC, Athens GA,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06119581

Phase 3, Recruiting

A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)

for
Acute Leukemia
Location: Knoxville TN, Indianapolis IN, Richmond VA, Chicago IL,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 2+

Code: NCT04811560

Phase 1, Phase 2, Recruiting

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

for
Urothelial Carcinoma
Location: Knoxville TN, Gastonia NC, Charlotte NC, Concord NC,
Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All

Age: 18+

Code: NCT04879329

Phase 2, Recruiting

A First in Human Study of the Safety, Tolerability, and the Physiologically Based Pharmacokinetics of XFB19 in Healthy Adult Volunteers.

for
Focus of the Study: Safety of XFB19
Location: Knoxville TN
Sponsor: Xfibra, Inc.

Sex: All

Age: 18 - 55

Code: NCT05361733

Phase 1, Recruiting

Moda-flx Hemodialysis System™ Under Professional Care Settings by Trained Individuals and At Home by Participants

for
End Stage Kidney Disease
Location: Knoxville TN, New Hyde Park NY, Houston TX,
Sponsor: Diality Inc.

Sex: All

Age: 18 - 70+

Code: NCT06613568

Recruiting

Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)

for
End Stage Kidney Disease
Location: Knoxville TN, Chattanooga TN, Greenville SC,
Sponsor: CSL Behring

Sex: All

Age: 18+

Code: NCT05485961

Phase 2, Phase 3, Recruiting

Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS

for
Acute Coronary Syndrome
Location: Powell TN, Oak Ridge TN, Jefferson City TN,
Sponsor: DalCor Pharmaceuticals

Sex: All

Age: 45+

Code: NCT05918861

Phase 3, Recruiting

Neuroinflammation and Alzheimer's Pathology in POCD

for
Post-Operative Confusion, Neuroinflammatory Response,
Location: Knoxville TN
Sponsor: University of Tennessee Graduate School of Medicine

Sex: All

Age: 60+

Code: NCT05378659

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity

for
Obesity
Location: Knoxville TN, Lexington KY, Kansas City MO, Doral FL
Sponsor: MBX Biosciences

Sex: All

Age: 18 - 65

Code: NCT07142707

Phase 1, Recruiting

A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

for
Chronic Idiopathic Constipation (CIC)
Location: Knoxville TN, Bristol TN, Woodstock GA, Marietta GA,
Sponsor: Ardelyx

Sex: All

Age: 18 - 70+

Code: NCT07382167

Phase 3, Recruiting

A Study to Investigate Velzatinib Compared With Imatinib in Adult Participants With Previously Untreated Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (StrateGIST Frontline)

for
Gastrointestinal Stromal Neoplasms
Location: Knoxville TN, Durham NC, Canton OH, Bethesda MD,
Sponsor: GlaxoSmithKline

Sex: All

Age: 18+

Code: NCT07585266

Phase 3, Recruiting

A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

for
Gastrointestinal Neoplasms
Location: Knoxville TN, Spartanburg SC, Charlotte NC, Durham NC,
Sponsor: GlaxoSmithKline

Sex: All

Age: 18+

Code: NCT07218926

Phase 3, Recruiting