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Paid Clinical Trials Knoxville

Discover 213 paid clinical trials in Knoxville, Tennessee. Search by condition or phase to find a research study near you that matches your needs across various therapeutic areas.

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Use of Impedance Cardiography to Decrease the Risk of Pre-eclampsia in Obese Patients

for
Obesity, Morbid, Preeclampsia
Location: Knoxville TN
Sponsor: University of Tennessee Graduate School of Medicine

Sex: Female

Age: 18 - 51

Code: NCT03105661

Early_phase1, Recruiting

Relationship Between Aspirin Metabolism and Markers of Metabolic Dysfunction Among Pregnant Persons at Risk of Pre-eclampsia

for
Preeclampsia, Preeclampsia (PE), Preeclampsia (PE) Risk,
Location: Knoxville TN
Sponsor: University of Tennessee Graduate School of Medicine

Sex: Female

Age: 18 - 45

Code: NCT06802861

Recruiting

A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

for
Diffuse Large B-Cell Lymphoma
Location: Knoxville TN, Greenville SC, Athens GA, Lexington KY,
Sponsor: Merck Sharp & Dohme LLC

Sex: All

Age: 18+

Code: NCT06717347

Phase3, Recruiting

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

for
Carcinoma, Non-Small-Cell Lung
Location: Knoxville TN, Chattanooga TN, Lexington KY, Atlanta GA,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06890598

Phase3, Recruiting

Y90 Radioembolization Dose Delivery and Radiation Exposure Assessment

for
Hepatocellular Carcinoma, Radiation Exposure
Location: Knoxville TN
Sponsor: University of Tennessee

Sex: All

Age: 18+

Code: NCT03686709

Recruiting

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A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

for
Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis
Location: Knoxville TN, Chattanooga TN, Greenville SC, Athens GA,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT06119581

Phase3, Recruiting

A Phase 1/2 Study of Bleximenib in Participants With Acute Leukemia (cAMeLot-1)

for
Acute Leukemia
Location: Knoxville TN, Indianapolis IN, Richmond VA, Chicago IL,
Sponsor: Janssen Research & Development, LLC

Sex: All

Age: 2+

Code: NCT04811560

Phase1, Phase2, Recruiting

A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2

for
Urothelial Carcinoma
Location: Knoxville TN, Gastonia NC, Charlotte NC, Concord NC,
Sponsor: Seagen, a wholly owned subsidiary of Pfizer

Sex: All

Age: 18+

Code: NCT04879329

Phase2, Recruiting

Efficacy of PP-01 in Mitigating Cannabis Withdrawal Symptoms in Adults With Cannabis Use Disorder

for
Cannabis Withdrawal
Location: Knoxville TN, Norcross GA, Lexington KY, Decatur GA,
Sponsor: PleoPharma, Inc.

Sex: All

Age: 18 - 55

Code: NCT07644052

Phase3, Recruiting

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

for
Osteoarthritis
Location: Knoxville TN, Woodstock GA, Decatur GA, Shelby NC,
Sponsor: Eli Lilly and Company

Sex: All

Age: 18+

Code: NCT07153471

Phase3, Recruiting

A First in Human Study of the Safety, Tolerability, and the Physiologically Based Pharmacokinetics of XFB19 in Healthy Adult Volunteers.

for
Focus of the Study: Safety of XFB19
Location: Knoxville TN
Sponsor: Xfibra, Inc.

Sex: All

Age: 18 - 55

Code: NCT05361733

Phase1, Recruiting

Moda-flx Hemodialysis System™ Under Professional Care Settings by Trained Individuals and At Home by Participants

for
End Stage Kidney Disease
Location: Knoxville TN, New Hyde Park NY, Houston TX,
Sponsor: Diality Inc.

Sex: All

Age: 18 - 70+

Code: NCT06613568

Recruiting

Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)

for
End Stage Kidney Disease
Location: Knoxville TN, Chattanooga TN, Spartanburg SC,
Sponsor: CSL Behring

Sex: All

Age: 18+

Code: NCT05485961

Phase2, Phase3, Recruiting

Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS

for
Acute Coronary Syndrome
Location: Powell TN, Oak Ridge TN, Jefferson City TN,
Sponsor: DalCor Pharmaceuticals

Sex: All

Age: 45+

Code: NCT05918861

Phase3, Recruiting

Neuroinflammation and Alzheimer's Pathology in POCD

for
Post-Operative Confusion, Neuroinflammatory Response,
Location: Knoxville TN
Sponsor: University of Tennessee Graduate School of Medicine

Sex: All

Age: 60+

Code: NCT05378659

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MBX 4291 in Adult Participants With Obesity

for
Obesity
Location: Knoxville TN, Lexington KY, Kansas City MO, Doral FL
Sponsor: MBX Biosciences

Sex: All

Age: 18 - 65

Code: NCT07142707

Phase1, Recruiting

Efficacy and Safety of Oral KAI-7535 in Adult Participants Living With Obesity or Overweight With at Least 1 Weight-Related Comorbidity

for
Obesity, Overweight
Location: Knoxville TN, Spartanburg SC, Decatur GA,
Sponsor: Kailera

Sex: All

Age: 18 - 70+

Code: NCT07497880

Phase2, Recruiting

A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults

for
Chronic Idiopathic Constipation (CIC)
Location: Knoxville TN, Bristol TN, Woodstock GA, Marietta GA,
Sponsor: Ardelyx

Sex: All

Age: 18 - 70+

Code: NCT07382167

Phase3, Recruiting
New

A Study to Investigate Velzatinib Compared With Imatinib in Adult Participants With Previously Untreated Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (StrateGIST Frontline)

for
Gastrointestinal Stromal Neoplasms
Location: Knoxville TN, Canton OH, Omaha NE, Toronto
Sponsor: GlaxoSmithKline

Sex: All

Age: 18+

Code: NCT07585266

Phase3, Recruiting

A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib Therapy

for
Gastrointestinal Neoplasms
Location: Knoxville TN, Spartanburg SC, Charlotte NC, Durham NC,
Sponsor: GlaxoSmithKline

Sex: All

Age: 18+

Code: NCT07218926

Phase3, Recruiting